类风湿关节炎中的瓜氨酸免疫：CD8 T细胞登场。 - Suppr

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超能文献

Citrulline immunity in RA: CD8 T cells enter the scene.

作者信息

Chemin Karine, Malmström Vivianne

机构信息

Division of Rheumatology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.

Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

出版信息

Nat Rev Rheumatol. 2023 May;19(5):259-260. doi: 10.1038/s41584-023-00945-1.

DOI:10.1038/s41584-023-00945-1

PMID:36914789

Abstract

摘要

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Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies.瓜氨酸是类风湿关节炎特异性自身抗体所识别的抗原决定簇的重要组成部分。

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Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1 shared epitope alleles.类风湿关节炎中的抗瓜氨酸化纤维连接蛋白抗体与人类白细胞抗原-DRB1 共享表位等位基因相关。

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Rheumatoid arthritis antigens homocitrulline and citrulline are generated by local myeloperoxidase and peptidyl arginine deiminases 2, 3 and 4 in rheumatoid nodule and synovial tissue.类风湿关节炎抗原高瓜氨酸和瓜氨酸是由类风湿结节和滑膜组织中的局部髓过氧化物酶以及肽基精氨酸脱亚氨酶2、3和4产生的。

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Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis.类风湿关节炎中B淋巴细胞分泌抗含瓜氨酸肽抗体

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Activating mutations in CD8+ T-cells correlate to serological positivity in rheumatoid arthritis.CD8+ T 细胞中的激活突变与类风湿关节炎的血清学阳性相关。

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本文引用的文献

Cytotoxic CD8 T cells target citrullinated antigens in rheumatoid arthritis.细胞毒性 CD8 T 细胞靶向类风湿关节炎中的瓜氨酸化抗原。

Nat Commun. 2023 Jan 19;14(1):319. doi: 10.1038/s41467-022-35264-8.

Single cell sequencing identifies clonally expanded synovial CD4 T cells expressing GPR56 in rheumatoid arthritis.单细胞测序鉴定类风湿关节炎中表达 GPR56 的克隆性扩增滑膜 CD4 T 细胞。

Nat Commun. 2022 Jul 13;13(1):4046. doi: 10.1038/s41467-022-31519-6.

Granzyme K CD8 T cells form a core population in inflamed human tissue.颗粒酶 K+CD8+T 细胞构成人炎症组织内的核心细胞群。

Sci Transl Med. 2022 Jun 15;14(649):eabo0686. doi: 10.1126/scitranslmed.abo0686.

Genetics of rheumatoid arthritis.类风湿关节炎的遗传学。

Semin Immunopathol. 2022 Jan;44(1):47-62. doi: 10.1007/s00281-022-00912-0. Epub 2022 Jan 27.

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis.病理上扩增的外周辅助性T细胞亚群驱动类风湿关节炎中的B细胞。

Nature. 2017 Feb 1;542(7639):110-114. doi: 10.1038/nature20810.

CD8+ T cell profiles in patients with rheumatoid arthritis and their relationship to disease activity.类风湿关节炎患者的 CD8+ T 细胞特征及其与疾病活动的关系。

Arthritis Rheumatol. 2015 Feb;67(2):363-71. doi: 10.1002/art.38941.

Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis.免疫介导的孔形成途径导致细胞过度瓜氨酸化，并在类风湿关节炎中产生瓜氨酸化自身抗原。

Sci Transl Med. 2013 Oct 30;5(209):209ra150. doi: 10.1126/scitranslmed.3006869.

Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1*0401-positive humanized mice and rheumatoid arthritis patients.在 HLA-DRB1*0401 阳性人源化小鼠和类风湿性关节炎患者中对瓜氨酸化波形蛋白有反应的 T 细胞的鉴定及功能特征分析

Arthritis Rheum. 2011 Oct;63(10):2873-83. doi: 10.1002/art.30445.

Cytomegalovirus seropositivity is associated with the expansion of CD4+CD28- and CD8+CD28- T cells in rheumatoid arthritis.巨细胞病毒血清反应阳性与类风湿关节炎中CD4+CD28-和CD8+CD28- T细胞的扩增相关。

J Rheumatol. 1999 Jul;26(7):1452-7.

Oligoclonality of V beta 3 TCR chains in the CD8+ T cell population of rheumatoid arthritis patients.类风湿关节炎患者CD8+ T细胞群体中Vβ3 TCR链的寡克隆性

J Immunol. 1996 Jan 15;156(2):852-8.

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