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静脉-动脉体外膜肺氧合辅助下甲状旁腺癌合并严重循环及呼吸衰竭所致高钙血症危象的甲状旁腺切除术:一例报告

Venoarterial-extra corporeal membrane oxygenation-assisted parathyroidectomy for hypercalcemic crisis due to parathyroid carcinoma complicated by severe circulatory and respiratory failure: a case report.

作者信息

Enomoto Yuria, Matsuda Yuko, Nagamine Yusuke, Goto Takahisa

机构信息

Department of Anesthesiology and Critical Care Medicine, Yokohama City University Hospital, 3-9 Fukuura, Kanazawa-Ku, Kanagawa, 236-0004, Yokohama, Japan.

出版信息

JA Clin Rep. 2023 Mar 14;9(1):14. doi: 10.1186/s40981-023-00606-y.

Abstract

BACKGROUND

Hypercalcemia crisis is a rare but severe form of hypercalcemia complicated by multiple organ failure. Hypercalcemia crisis due to hyperparathyroidism is commonly caused by a parathyroid tumor, which often requires surgical resection. However, there are no clear recommendations on when the surgery should be performed.

CASE PRESENTATION

A 64-year-old female patient developed hyperparathyroidism due to a parathyroid tumor and hypercalcemic crisis, which was complicated by severe circulatory and respiratory failure refractory to medical therapy, and an emergent surgery was planned to resect the parathyroid tumor. To prevent intraoperative circulatory and respiratory collapse, venoarterial-extra corporeal membrane oxygenation (VA-ECMO) was introduced, resulting in a safe operation and anesthetic management.

CONCLUSIONS

In patients with hypercalcemic crisis complicated by severe circulatory and respiratory failure, induction of prophylactic VA-ECMO was useful for safe anesthetic management. Surgical resection should be performed as soon as the diagnosis is made before VA-ECMO is required.

摘要

背景

高钙血症危象是一种罕见但严重的高钙血症形式,常并发多器官功能衰竭。甲状旁腺功能亢进引起的高钙血症危象通常由甲状旁腺肿瘤所致,常需手术切除。然而,对于何时进行手术尚无明确建议。

病例报告

一名64岁女性患者因甲状旁腺肿瘤并发甲状旁腺功能亢进及高钙血症危象,伴有严重循环和呼吸衰竭,药物治疗无效,遂计划紧急手术切除甲状旁腺肿瘤。为防止术中循环和呼吸衰竭,采用了静脉-动脉体外膜肺氧合(VA-ECMO),实现了安全的手术和麻醉管理。

结论

对于并发严重循环和呼吸衰竭的高钙血症危象患者,预防性应用VA-ECMO有助于安全的麻醉管理。一旦确诊,应在需要VA-ECMO之前尽快进行手术切除。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a77d/10011232/acb5be1eb3ab/40981_2023_606_Fig1_HTML.jpg

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