纤毛力学感知的争论变得（具有）生物物理性质。
The cilia mechanosensation debate gets (bio)physical.
机构信息
Institute of Innate Immunity, Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany.
MRC Human Genetics Unit, Institute for Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
出版信息
Nat Rev Nephrol. 2023 May;19(5):279-280. doi: 10.1038/s41581-023-00701-4.
Abstract
For the first time, two new studies applied a mechanical stimulus directly to a cilium, independent of a chemical signal, and demonstrated that force-based bending of a single nodal axoneme is sufficient to induce intraciliary Ca flux in a PKD2-dependent manner, which propagated to drive asymmetric gene expression.
摘要
首次有两项新研究独立于化学信号，直接对纤毛施加机械刺激，并证实了单个动纤毛的力致弯曲足以诱导依赖 PKD2 的纤毛内 Ca 流，该 Ca 流传播进而驱动不对称基因表达。
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