放射治疗肛周基底鳞状细胞癌：一例报告
Perianal basosquamous carcinoma treated with radiation therapy, a case report.
作者信息
Kwan Stephanie Y, Castillo Dani Ran, Aka Allison A, Kandala Gokul, Tsai James Y, Zmaj Kristine, Reeves Mark E, Yang Gary Y
机构信息
Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA.
Division of Hematology/Oncology, Loma Linda University Medical Center, Loma Linda, CA, USA.
出版信息
J Gastrointest Oncol. 2023 Feb 28;14(1):463-467. doi: 10.21037/jgo-22-1244. Epub 2023 Feb 24.
BACKGROUND
Perianal basal cell carcinoma (BCC) is very rare and estimated to account for 0.08% of all BCC and 0.02% of all anorectal neoplasms. Perianal lesions are more likely to be squamous cell carcinoma (SCC) as BCC usually develops on areas of skin exposed to ultraviolet (UV) light such as the face and arms. Proper diagnosis with the assistance of immunohistochemistry (IHC) stains to distinguish the two entities can help inform the suitable course of treatment.
CASE DESCRIPTION
Our case is an 82-year-old male with a history of cutaneous BCC on the arms and trunk presenting with a symptomatic perianal lesion. Initial biopsy demonstrated BCC with subsequent IHC studies differentiating from basaloid SCC. Standard treatment includes wide local excision (WLE) but given his poor performance status, radiation only was recommended. He was successfully treated and tolerated 30 Gy in 5 daily fractions.
CONCLUSIONS
Radiation only is a unique and feasible non-surgical treatment for basosquamous carcinoma of the anus.
背景
肛周基底细胞癌（BCC）非常罕见，估计占所有基底细胞癌的0.08%，占所有肛肠肿瘤的0.02%。肛周病变更可能是鳞状细胞癌（SCC），因为基底细胞癌通常发生在暴露于紫外线（UV）的皮肤区域，如面部和手臂。借助免疫组织化学（IHC）染色进行正确诊断以区分这两种实体，有助于确定合适的治疗方案。
病例描述
我们的病例是一名82岁男性，有手臂和躯干皮肤基底细胞癌病史，出现有症状的肛周病变。最初的活检显示为基底细胞癌，随后的免疫组织化学研究将其与基底样鳞状细胞癌区分开来。标准治疗包括广泛局部切除（WLE），但鉴于他的身体状况较差，仅建议进行放疗。他成功接受了治疗，每日5次分割，共30 Gy，耐受性良好。
结论
单纯放疗是一种独特且可行的肛门基底鳞状细胞癌非手术治疗方法。
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