Hyötyläinen Tuulia, Karthikeyan Bagavathy Shanmugam, Ghaffarzadegan Tannaz, Triplett Eric W, Orešič Matej, Ludvigsson Johnny
School of Science and Technology, Örebro University, 702 81 Örebro, Sweden.
School of Medical Sciences, Örebro University, 702 81 Örebro, Sweden.
iScience. 2023 Feb 25;26(3):106268. doi: 10.1016/j.isci.2023.106268. eCollection 2023 Mar 17.
Previous prospective studies suggest that progression to autoimmune diseases is preceded by metabolic dysregulation, but it is not clear which metabolic changes are disease-specific and which are common across multiple immune-mediated diseases. Here we investigated metabolic profiles in cord serum in a general population cohort (All Babies In Southeast Sweden; ABIS), comprising infants who progressed to one or more immune-mediated diseases later in life: type 1 diabetes (n = 12), celiac disease (n = 28), juvenile idiopathic arthritis (n = 9), inflammatory bowel disease (n = 7), and hypothyroidism (n = 6); and matched controls (n = 270). We observed elevated levels of multiple triacylglycerols (TGs) an alteration in several gut microbiota related metabolites in the autoimmune groups. The most distinct differences were observed in those infants who later developed HT. The specific similarities observed in metabolic profiles across autoimmune diseases suggest that they share specific common metabolic phenotypes at birth that contrast with those of healthy controls.
先前的前瞻性研究表明，自身免疫性疾病的进展之前存在代谢失调，但尚不清楚哪些代谢变化是疾病特异性的，哪些是多种免疫介导疾病共有的。在此，我们在一个普通人群队列（瑞典东南部所有婴儿；ABIS）中研究了脐带血清中的代谢谱，该队列包括后来发展为一种或多种免疫介导疾病的婴儿：1型糖尿病（n = 12）、乳糜泻（n = 28）、幼年特发性关节炎（n = 9）、炎症性肠病（n = 7）和甲状腺功能减退（n = 6）；以及匹配的对照组（n = 270）。我们观察到自身免疫组中多种三酰甘油（TGs）水平升高以及几种肠道微生物群相关代谢物的改变。在后来患甲状腺功能减退症的婴儿中观察到最明显的差异。在自身免疫性疾病的代谢谱中观察到的特定相似性表明，它们在出生时具有特定的共同代谢表型，这与健康对照组不同。
