Kawamoto Ryuichi, Kikuchi Asuka, Ninomiya Daisuke, Kumagi Teru
Department of Community Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
Department of Internal Medicine, Seiyo Municipal Nomura Hospital, Seiyo, Japan.
Int J Anal Chem. 2023 Mar 4;2023:7382320. doi: 10.1155/2023/7382320. eCollection 2023.
There is limited research on the association between longitudinal variability in serum uric acid (SUA) and all-cause mortality in the general population, although recent studies have suggested that changes in SUA are associated with all-cause mortality in adults. This study aims to examine the association between percentage change in SUA (%dSUA = 100 × (cohort 2 SUA - cohort 1 SUA)/(time × cohort 1 SUA) and all-cause mortality. This study is based on 1,301 participants, of whom 543 were male (63 ± 11 years) and 758 were female (63 ± 9 years). We obtained adjusted relative risk estimates for all-cause mortality and used a Cox proportional hazards model, adjusted for possible confounders, to determine the hazard ratio (HR) and 95% confidence interval (CI) of %dSUA. Of all the participants, 79 (6.1%) were deceased, and of these, 45 were male (8.3%) and 34 were female (4.5%). The multivariable-adjusted HRs (95% CI) for all-cause mortality for the first, second to fourth (reference), and fifth %dSUA quintiles were 3.79 (1.67-8.48), 1.00, and 0.87 (0.29-2.61) for male participants and 4.00 (1.43-11.2), 1.00, and 1.19 (0.46-3.05) for female participants, respectively. Participants with a body mass index of <22 kg/m had a significantly higher HR, forming a -shaped curve for the first (HR, 7.59; 95% CI, 2.13-27.0) and fifth quintiles (HR, 2.93; 95% CI, 1.05-8.18) relative to the reference. Percentage change in SUA is independently and significantly associated with future all-cause mortality among community-dwelling persons.
虽然最近的研究表明血清尿酸（SUA）的变化与成年人的全因死亡率有关，但关于普通人群中SUA的纵向变异性与全因死亡率之间关联的研究有限。本研究旨在探讨SUA百分比变化（%dSUA = 100×（队列2的SUA - 队列1的SUA）/（时间×队列1的SUA））与全因死亡率之间的关联。本研究基于1301名参与者，其中543名男性（63±11岁），758名女性（63±9岁）。我们获得了全因死亡率的调整后相对风险估计值，并使用Cox比例风险模型，对可能的混杂因素进行调整，以确定%dSUA的风险比（HR）和95%置信区间（CI）。在所有参与者中，79人（6.1%）死亡，其中45名男性（8.3%），34名女性（4.5%）。男性参与者中，第一、第二至第四（参照）和第五%dSUA五分位数的全因死亡率的多变量调整后HR（95%CI）分别为3.79（1.67 - 8.48）、1.00和0.87（0.29 - 2.61）；女性参与者分别为4.00（1.43 - 11.2）、1.00和1.19（0.46 - 3.05）。体重指数<22 kg/m²的参与者的HR显著更高，相对于参照组，第一（HR，7.59；95%CI，2.13 - 27.0）和第五五分位数形成一条倒U形曲线（HR，2.93；95%CI，1.05 - 8.18）。SUA的百分比变化与社区居住人群未来的全因死亡率独立且显著相关。
