细胞分裂周期蛋白20（CDC20）：癌症中的新型治疗靶点。
CDC20: a novel therapeutic target in cancer.
作者信息
He Wenning, Meng Jun
机构信息
Department of Laboratory Medicine, The Affiliated Hospital of Inner Mongolia Medical University Hohhot 010050, Inner Mongolia Autonomous Region, P. R. China.
出版信息
Am J Transl Res. 2023 Feb 15;15(2):678-693. eCollection 2023.
Abstract
Cell division cycle protein 20 (Cdc20) is a member of the cell cyclin family. In the early stage of mitosis, it activates the anaphase-promoting complex (APC) and forms the E3 ubiquitin ligase complex APC, which destroys key regulators of the cell cycle and promotes mitosis. Cdc20 serves as a target for the spindle checkpoint, ensuring proper chromosome segregation. As an oncoprotein, Cdc20 is highly expressed in a variety of malignant tumors, and Cdc20 overexpression is associated with poor prognosis of these tumors. This review aims to dissect the tumorigenic role of Cdc20 in human malignancies and its targeting strategies.
摘要
细胞分裂周期蛋白20（Cdc20）是细胞周期蛋白家族的成员。在有丝分裂早期，它激活后期促进复合物（APC）并形成E3泛素连接酶复合物APC，该复合物破坏细胞周期的关键调节因子并促进有丝分裂。Cdc20作为纺锤体检查点的靶点，确保染色体正确分离。作为一种癌蛋白，Cdc20在多种恶性肿瘤中高表达，且Cdc20过表达与这些肿瘤的不良预后相关。本综述旨在剖析Cdc20在人类恶性肿瘤中的致瘤作用及其靶向策略。
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