Liu Qi, Liang Jieyu, Liu Ze, Mei Haibo, Zhu Guanghui, Guo Hongbin, Wang Min, Zhang Yi
Department of Orthopaedics, Xiangya Hospital, Central South University Changsha, Hunan, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University Changsha, Hunan, China.
Am J Transl Res. 2023 Feb 15;15(2):1247-1253. eCollection 2023.
The traditional pixel value ratio (tPVR) is subject to disuse osteopenia of the adjacent bone in distraction osteogenesis (DO). Therefore, a modified PVR (mPVR) based on the contralateral normal bone was developed and validated to address this issue.
A total of 79 bone lengthening subjects were recruited in this retrospective study. The difference between the mPVR and tPVR of early callus was identified in the first three months after osteotomy. Moreover, we further investigated the relationship between mPVR and healing index (HI), lengthening index (LI) and external fixator index (EFI). Finally, the potential influencing factors for mPVR of the early callus were analyzed.
The mPVR was significantly lower than the tPVR in the first three months after osteotomy, and the difference gradually increased. Interestingly, the mPVR of the early callus in the first two months was negatively correlated with the HI, LI and EFI. Moreover, the age, lengthening site, total bilirubin and mean hemoglobin content were associated with the mPVR of early callus during DO.
The mPVR based on contralateral normal bone is a novel reliable indicator for DO, which may be helpful for the clinical management of DO. However, the findings of this study need to be confirmed further by larger prospective research.
在牵张成骨（DO）中，传统的像素值比率（tPVR）受相邻骨废用性骨质减少的影响。因此，开发并验证了一种基于对侧正常骨的改良PVR（mPVR）来解决这一问题。
本回顾性研究共纳入79例骨延长患者。在截骨后的前三个月确定早期骨痂的mPVR与tPVR之间的差异。此外，我们进一步研究了mPVR与愈合指数（HI）、延长指数（LI）和外固定指数（EFI）之间的关系。最后，分析了早期骨痂mPVR的潜在影响因素。
截骨后的前三个月，mPVR显著低于tPVR，且差异逐渐增大。有趣的是，前两个月早期骨痂的mPVR与HI、LI和EFI呈负相关。此外，年龄、延长部位、总胆红素和平均血红蛋白含量与DO期间早期骨痂的mPVR有关。
基于对侧正常骨的mPVR是一种用于DO的新型可靠指标，可能有助于DO的临床管理。然而，本研究结果需要通过更大规模的前瞻性研究进一步证实。
