R 56865可预防豚鼠乳头肌哇巴因中毒的电和机械征象。
R 56865 prevents electrical and mechanical signs of ouabain intoxication in guinea-pig papillary muscle.
作者信息
Vollmer B, Meuter C, Janssen P A
机构信息
Janssen Research Foundation, Neuss, F.R.G.
出版信息
Eur J Pharmacol. 1987 Oct 6;142(1):137-40. doi: 10.1016/0014-2999(87)90663-7.
The effect of the new compound R 56865 on ouabain-induced intoxication (8 X 10(-7) mol/l) was studied in guinea-pig papillary muscle. The positive inotropism induced by ouabain was not impaired by R 56865. Mechanical signs of intoxication, e.g. extrasystoles and contracture, as well as the development of spike-like action potentials could be prevented by pretreatment with R 56865 (3 X 10(-10)-10(-6) mol/l). We speculate that this new compound prevents ouabain-induced Ca overload of cardiac muscle.
在豚鼠乳头肌中研究了新型化合物R 56865对哇巴因诱导中毒（8×10⁻⁷mol/L）的影响。R 56865并未损害哇巴因诱导的正性肌力作用。中毒的机械性体征，如早搏和挛缩，以及尖峰样动作电位的出现，可通过用R 56865（3×10⁻¹⁰ - 10⁻⁶mol/L）预处理来预防。我们推测这种新化合物可防止哇巴因诱导的心肌钙超载。
Zotero 插件