Chen Yihui, Dong Peng, Zhang Xiyang
The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China.
Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong, China. Corresponding author: Zhang Xiyang, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2023 Feb;35(2):212-216. doi: 10.3760/cma.j.cn121430-20220919-00846.
Sepsis, a series of pathophysiological abnormalities caused by infection, is also one of the most important factors of death and disability in infected patients all over the world, so it has always been the focus of the medical community. Cytokines are small molecule proteins secreted by cells with biological activity, involved in the immune and inflammatory regulation of sepsis. Many studies using cytokine targeting to treat sepsis have achieved beneficial effects, and the level of cytokines is also believed to be related to the development, severity of sepsis, so they are reliable biomarkers of sepsis. Among them, pro-inflammatory cytokines such as interferon-β (IFN-β) and interleukins (IL-1β, IL-3, IL-6, and IL-7) are the focus of the discussion in this review. IFN-β and IL-1β are double-sided in the treatment of sepsis, namely early low-dose treatment can reduce sepsis by restoring the function of immune cells and play a protective effect, but they are also related to severe inflammatory response of sepsis and can aggravate the mortality of sepsis patients. IL-3 and IL-6 focus more on enhancing inflammatory factors and play a damage role. IL-7 mainly participates in immune regulation, promoting lymphocyte activation and protecting sepsis.
脓毒症是由感染引起的一系列病理生理异常，也是全球感染患者死亡和致残的最重要因素之一，因此一直是医学界关注的焦点。细胞因子是具有生物活性的细胞分泌的小分子蛋白质，参与脓毒症的免疫和炎症调节。许多使用细胞因子靶向治疗脓毒症的研究都取得了有益效果，细胞因子水平也被认为与脓毒症的发生、严重程度有关，因此它们是脓毒症可靠的生物标志物。其中，促炎细胞因子如干扰素-β（IFN-β）和白细胞介素（IL-1β、IL-3、IL-6和IL-7）是本综述讨论的重点。IFN-β和IL-1β在脓毒症治疗中具有两面性，即早期低剂量治疗可通过恢复免疫细胞功能减轻脓毒症并发挥保护作用，但它们也与脓毒症的严重炎症反应有关，可加重脓毒症患者的死亡率。IL-3和IL-6更侧重于增强炎症因子并发挥损害作用。IL-7主要参与免疫调节，促进淋巴细胞活化并保护脓毒症。
