电化学反应器可在 N-杂环芳烃的 C-H 羧化反应中实现不同位点的选择性。
Electrochemical Reactors Enable Divergent Site Selectivity in the C-H Carboxylation of N-Heteroarenes.
机构信息
College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei, 430079, China.
Wuhan Institute of Photochemistry and Technology, 7 North Bingang Road, Wuhan, Hubei, 430082, China.
出版信息
Angew Chem Int Ed Engl. 2023 May 15;62(21):e202302227. doi: 10.1002/anie.202302227. Epub 2023 Apr 7.
Catalytic and switchable C-H functionalization of N-heteroarenes under easily tunable conditions is a robust but challenging tool for the construction of biologically relevant compounds. Recently, a general electrochemical strategy has been developed for the direct C-H carboxylation of N-heteroarenes with CO , and by simply choosing different types of cell setups, carboxylated products are furnished with excellent and tunable site selectivity. This study also paves the way for regulating the reactivity modes in electrochemical synthesis.
在易于调控的条件下，实现 N-杂环芳烃的催化及可切换 C-H 官能化是构建具有生物相关性化合物的有力但具有挑战性的工具。最近，人们开发出一种通用的电化学策略，可直接实现 N-杂环芳烃与 CO 的 C-H 羧基化，并且通过简单地选择不同类型的电池设置，可获得具有优异且可调的位置选择性的羧化产物。这项研究还为调节电化学合成中的反应模式铺平了道路。
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