Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 116023 Dalian, Liaoning, China.
Leibniz-Institut für Katalyse e.V., 18059 Rostock, Germany.
Org Lett. 2023 Mar 24;25(11):1963-1968. doi: 10.1021/acs.orglett.3c00506. Epub 2023 Mar 14.
Carbenes are highly active reaction intermediates, which can be used as reaction precursors to modify organisms, drugs, and material molecules. In this work, we realized a new cheap metal-catalyzed carbonylation of carbene to give propanedioic acid derivatives. With copper salt as the catalyst, synthetically important malonates and related compounds were produced in good yields under mild reaction conditions.
卡宾是高活性的反应中间体，可用作反应前体来修饰生物体、药物和材料分子。在这项工作中，我们实现了一种新的廉价金属催化卡宾羰基化反应，得到了丙二酸衍生物。在温和的反应条件下，以铜盐为催化剂，高产率地合成了具有重要合成意义的丙二酸盐和相关化合物。
