Department of Psychology, University of Nevada Las Vegas, Las Vegas, Nevada, USA.
Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Bipolar Disord. 2023 Dec;25(8):648-660. doi: 10.1111/bdi.13320. Epub 2023 Mar 25.
This study benchmarks quality of life (QoL) of youth with bipolar disorder (BD) against healthy youth, youth with chronic medical conditions, and youth with other psychiatric disorders. The relative impacts of depressive, (hypo)manic, mixed, and externalizing symptoms on QoL are tested for youth with BD.
In total, 657 youth completed the Schedule for Affective Disorders and Schizophrenia for Children (KSADS), the KSADS depression and mania scales, the Parent General Behavior Inventory (PGBI), and the Child Behavior Checklist (CBCL). Youth-reported QoL was determined by the Revised Children Quality of Life Questionnaire (KINDL) and was compared to healthy youth, youth with chronic medical conditions, and youth with other psychiatric disorders.
Youth with BD reported poorer QoL overall and on most subscales compared to healthy youth, youth with chronic medical conditions, youth with behavior disorders, and youth with other non-behavior/non-mood disorders. QoL in youth with BD did not differ significantly from QoL in youth with unipolar depression. Parent-report and interview-rated depressive symptoms were associated with decreases in Total QoL and all QoL subscales except Family. Externalizing symptoms were associated with decreases in Family QoL and increases in Friend QoL, and (hypo)manic symptoms were associated with increases in Emotional Well-Being QoL.
Depressive symptoms may drive the decline in QoL causing youth with BD to rate their QoL worse than healthy youth, youth with chronic medical conditions, and youth with behavior disorders, but not worse than youth with unipolar depression.
本研究将双相情感障碍（BD）青年的生活质量（QoL）与健康青年、患有慢性疾病的青年和患有其他精神障碍的青年进行基准比较。本研究还检验了抑郁、（轻躁狂）、混合和外化症状对 BD 青年 QoL 的相对影响。
共有 657 名青年完成了儿童情感障碍和精神分裂症诊断性访谈表（KSADS）、KSADS 抑郁和躁狂量表、父母一般行为量表（PGBI）和儿童行为检查表（CBCL）。青年自我报告的 QoL 通过修订后的儿童生活质量问卷（KINDL）来确定，并与健康青年、患有慢性疾病的青年和患有其他精神障碍的青年进行比较。
与健康青年、患有慢性疾病的青年、患有行为障碍的青年以及患有其他非行为/非情绪障碍的青年相比，BD 青年总体上和大多数子量表上的 QoL 都较差。BD 青年的 QoL 与单相抑郁青年的 QoL 没有显著差异。父母报告和访谈评估的抑郁症状与总 QoL 和除家庭外的所有 QoL 子量表的下降有关。外化症状与家庭 QoL 的下降和朋友 QoL 的增加有关，而（轻躁狂）症状与情绪健康 QoL 的增加有关。
抑郁症状可能是导致 BD 青年 QoL 下降的原因，使他们对 QoL 的评价比健康青年、患有慢性疾病的青年和患有行为障碍的青年更差，但不比患有单相抑郁的青年更差。
