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Risk factors, presentation and outcome of meningomyelocele repair.脊髓脊膜膨出修补术的危险因素、临床表现及预后
Pak J Med Sci. 2020 Mar-Apr;36(3):422-425. doi: 10.12669/pjms.36.3.1237.
3
Folic Acid Fortification and Neural Tube Defect Risk: Analysis of the Food Fortification Initiative Dataset.叶酸强化与神经管缺陷风险：食物强化倡议数据集分析。
Nutrients. 2020 Jan 18;12(1):247. doi: 10.3390/nu12010247.
4
Neural tube defect diagnosis and outcomes at a tertiary South African hospital with intensive case ascertainment.南非一家三级医院通过强化病例发现对神经管缺陷的诊断和结局。
S Afr Med J. 2019 Aug 28;109(9):698-703. doi: 10.7196/SAMJ.2019.v109i9.13863.
5
Reviewing the prognostic factors in myelomeningocele.回顾脊髓脊膜膨出的预后因素。
Neurosurg Focus. 2019 Oct 1;47(4):E2. doi: 10.3171/2019.7.FOCUS19462.
6
Neural Tube Defects: A Retrospective Study of 69 Cases.神经管缺陷：69例回顾性研究
Asian J Neurosurg. 2019 Apr-Jun;14(2):506-509. doi: 10.4103/ajns.AJNS_300_18.
7
Neural tube defects in Uganda: follow-up outcomes from a national referral hospital.乌干达的神经管缺陷：来自一家国家转诊医院的随访结果。
Neurosurg Focus. 2018 Oct;45(4):E9. doi: 10.3171/2018.7.FOCUS18280.
8
Maternal risk factors associated with neural tube defects in Tigray regional state of Ethiopia.埃塞俄比亚提格雷州与神经管缺陷相关的孕产妇风险因素。
Brain Dev. 2019 Jan;41(1):11-18. doi: 10.1016/j.braindev.2018.07.013. Epub 2018 Jul 31.
9
Research: Prevalence of neural tube defects Khartoum, Sudan August 2014-July 2015.研究：神经管缺陷的患病率，苏丹喀土穆，2014年8月至2015年7月。
BMC Res Notes. 2016 Nov 24;9(1):495. doi: 10.1186/s13104-016-2298-6.
10
Risk factors for neural tube defects in Riyadh City, Saudi Arabia: Case-control study.沙特阿拉伯利雅得市神经管缺陷的危险因素：病例对照研究。
Sudan J Paediatr. 2014;14(2):49-60.

从产前诊断到出院的神经管缺陷- 一个三级学术中心的经验。

Neural Tube Defects from Antenatal Diagnosis to Discharge - a Tertiary Academic Centre Experience.

机构信息

Department of Pediatrics, Division of Neonatology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

出版信息

Med Arch. 2023 Feb;77(1):40-43. doi: 10.5455/medarh.2023.77.40-43.

DOI:10.5455/medarh.2023.77.40-43
PMID:36919133
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10008259/
Abstract

BACKGROUND

Bleeding Worldwide, approximately 300,000 infants are born annually with neural tube defects (NTDs), which carry a high risk of morbidity and mortality.

OBJECTIVE

The aim of the study was to describe the experience with NTD patients born at a tertiary academic center.

METHODS

A retrospective record review of all neonates with NTD admitted to the neonatal intensive care unit over six years.

RESULTS

Out of the 39 patients identified, 32 (82.1%) were diagnosed antenatally. Most NTD cases were of the myelomeningocele 26 (66.7%) type. The most common site of the myelomeningocele was lumbar, and the thoracolumbar site had the worst prognosis.

CONCLUSION

Early detection of the disease allows better planning of delivery and treatment decisions. Nevertheless, understanding the magnitude of the problem necessitates adopting public health prevention strategies for better outcomes.

摘要

背景

据统计，全球每年约有 30 万名婴儿出生时患有神经管缺陷（NTDs），这些患儿存在较高的发病率和死亡率。

目的

本研究旨在描述在一家三级学术中心出生的 NTD 患儿的诊治经验。

方法

对过去六年中入住新生儿重症监护病房的所有 NTD 新生儿进行回顾性病历记录审查。

结果

在确定的 39 名患者中，有 32 名（82.1%）患儿在产前被诊断出患有 NTD。大多数 NTD 病例为脊髓脊膜膨出（myelomeningocele）26 例（66.7%）。最常见的脊髓脊膜膨出部位是腰骶部，而胸腰骶部的预后最差。

结论

早期发现疾病可以更好地规划分娩和治疗决策。然而，要了解问题的严重程度，需要采取公共卫生预防策略，以获得更好的结果。