从产前诊断到出院的神经管缺陷- 一个三级学术中心的经验。
Neural Tube Defects from Antenatal Diagnosis to Discharge - a Tertiary Academic Centre Experience.
机构信息
Department of Pediatrics, Division of Neonatology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
出版信息
Med Arch. 2023 Feb;77(1):40-43. doi: 10.5455/medarh.2023.77.40-43.
BACKGROUND
Bleeding Worldwide, approximately 300,000 infants are born annually with neural tube defects (NTDs), which carry a high risk of morbidity and mortality.
OBJECTIVE
The aim of the study was to describe the experience with NTD patients born at a tertiary academic center.
METHODS
A retrospective record review of all neonates with NTD admitted to the neonatal intensive care unit over six years.
RESULTS
Out of the 39 patients identified, 32 (82.1%) were diagnosed antenatally. Most NTD cases were of the myelomeningocele 26 (66.7%) type. The most common site of the myelomeningocele was lumbar, and the thoracolumbar site had the worst prognosis.
CONCLUSION
Early detection of the disease allows better planning of delivery and treatment decisions. Nevertheless, understanding the magnitude of the problem necessitates adopting public health prevention strategies for better outcomes.
背景
据统计，全球每年约有 30 万名婴儿出生时患有神经管缺陷（NTDs），这些患儿存在较高的发病率和死亡率。
目的
本研究旨在描述在一家三级学术中心出生的 NTD 患儿的诊治经验。
方法
对过去六年中入住新生儿重症监护病房的所有 NTD 新生儿进行回顾性病历记录审查。
结果
在确定的 39 名患者中，有 32 名（82.1%）患儿在产前被诊断出患有 NTD。大多数 NTD 病例为脊髓脊膜膨出（myelomeningocele）26 例（66.7%）。最常见的脊髓脊膜膨出部位是腰骶部，而胸腰骶部的预后最差。
结论
早期发现疾病可以更好地规划分娩和治疗决策。然而，要了解问题的严重程度，需要采取公共卫生预防策略，以获得更好的结果。
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