Rørvik Synne Dragesund, Abrahamsen Ingerid Weum, Myhre Anders Eivind, Vo Camilla Dao, Ødegaard Eva Meling, Bruserud Øystein, Gedde-Dahl Tobias, Tvedt Tor Henrik Anderson
Hjerteavdelingen, Haukeland universitetssjukehus.
Avdeling for blodsykdommer, Oslo universitetssykehus.
Tidsskr Nor Laegeforen. 2023 Mar 13;143(4). doi: 10.4045/tidsskr.22.0525. Print 2023 Mar 14.
Chronic graft-versus-host disease is a late complication of allogeneic stem cell transplantation and leads to chronic inflammation and fibrosis in various organs due to dysregulation of donor immune cells. The disease can occur in all organs, but is most frequently seen in the skin, eyes, oral cavity, gastrointestinal tract, genitalia, lungs, muscles, fascia and joints. Chronic graft-versus-host disease is associated with considerable morbidity and mortality, and treatment requires close collaboration between different parts of the specialist health services. This article provides a clinical review of chronic graft-versus-host disease based on a non-systematic literature search and the authors' own clinical experience.
慢性移植物抗宿主病是异基因干细胞移植的晚期并发症，由于供体免疫细胞失调，可导致各器官的慢性炎症和纤维化。该病可发生于所有器官，但最常见于皮肤、眼睛、口腔、胃肠道、生殖器、肺、肌肉、筋膜和关节。慢性移植物抗宿主病与相当高的发病率和死亡率相关，治疗需要专科医疗服务不同部门之间的密切协作。本文基于非系统性文献检索和作者自身临床经验，对慢性移植物抗宿主病进行临床综述。
