3,4-/3,5-二羟基苯甲酸的非化学计量卡马西平共晶水合物：共形成物-水交换
Non-stoichiometric carbamazepine cocrystal hydrates of 3,4-/3,5-dihydroxybenzoic acids: coformer-water exchange.
作者信息
Rajbongshi Trishna, Sarmah Kashyap Kumar, Das Susobhan, Deka Poonam, Saha Arijit, Saha Binoy K, Puschmann Horst, Reddy C Malla, Thakuria Ranjit
机构信息
Department of Chemistry, Gauhati University, Guwahati, 781014, India.
Department of Chemistry, Behali Degree College, Borgang, Biswanath, 784167, Assam, India.
出版信息
Chem Commun (Camb). 2023 Mar 28;59(26):3902-3905. doi: 10.1039/d2cc06860e.
The cocrystallisation of carbamazepine (CBZ) with 3,4-/3,5-dihydroxybenzoic acids (34/35DHBA) with different stoichiometries formed molecular alloys, exchanging a water molecule, in their isostructural CBZ dihydrate form. Furthermore, we show a correlation between the mechanical properties of the CBZ-DHBA cocrystals with the amount of coformer present.
卡马西平（CBZ）与不同化学计量比的3,4-/3,5-二羟基苯甲酸（34/35DHBA）共结晶形成了分子合金，它们以同构的CBZ二水合物形式交换了一个水分子。此外，我们还展示了CBZ-DHBA共晶体的机械性能与共形成剂含量之间的相关性。
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