Hansen Niels, Müller Sebastian Johannes, Khadhraoui Eya, Ernst Marielle, Riedel Christian Heiner, Wiltfang Jens, Lange Claudia, Bouter Carolin
Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Institute of Diagnostic and Interventional Neuroradiology, University Medical Center Göttingen, Göttingen, Germany.
World J Biol Psychiatry. 2023 Sep-Oct;24(7):558-563. doi: 10.1080/15622975.2023.2191008. Epub 2023 Apr 12.
Our article is dedicated to describing the state-of-the-art in imaging techniques for assessing prodromal dementia with Lewy bodies (pro-DLB) with a psychiatric-onset.
Imaging biomarker techniques are discussed.
(123)-I-2-ß-carbomethoxy-3ß-(4-iodophenyl)--(3-fluoropropyl) nortropane single photon emission computed tomography (123I-FP-CIT SPECT) seems to be a promising method as it reveals abnormalities in pro-DLB with a psychiatric-onset. New potential biomarkers can be revealed novel techniques, such as manual segmentation in magnetic resonance imaging (MRI), which helps detect atrophy of the substantia innominata in pro-DLB with a psychiatric-onset as opposed to an onset with mild cognitive impairment (MCI). FDG-PET can also help us distinguish patients with mixed pro-DLB from those pro-DLB patients with a psychiatric-onset or MCI-onset. Changes in large-scale networks in the posterior standard mode and in attentional networks could be early signs in resting-state functional MRI to characterise pro-DLB.
In conclusion, there is a wide range of techniques that need to be explored in large-scale studies and are of promising value in understanding pro-DLB with a psychiatric-onset.
我们的文章致力于描述用于评估伴有精神症状的前驱性路易体痴呆（pro-DLB）的成像技术的最新进展。
讨论了成像生物标志物技术。
（123）-I-2-β-甲氧基羰基-3β-（4-碘苯基）-（3-氟丙基）去甲托烷单光子发射计算机断层扫描（123I-FP-CIT SPECT）似乎是一种有前景的方法，因为它能揭示伴有精神症状的pro-DLB的异常情况。新的潜在生物标志物可通过新技术揭示，如磁共振成像（MRI）中的手动分割，这有助于检测伴有精神症状而非轻度认知障碍（MCI）起病的pro-DLB中无名质的萎缩。氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）也能帮助我们区分混合性pro-DLB患者与伴有精神症状或MCI起病的pro-DLB患者。后标准模式下大规模网络和注意力网络的变化可能是静息态功能MRI中表征pro-DLB的早期迹象。
总之，有多种技术需要在大规模研究中探索，并且在理解伴有精神症状的pro-DLB方面具有潜在价值。
