University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Department of Pharmaceutical and Administrative Sciences, Loma Linda University, Loma Linda, CA, USA.
Cell Transplant. 2023 Jan-Dec;32:9636897231158967. doi: 10.1177/09636897231158967.
The field of stem cell therapy is growing rapidly and hopes to offer an alternative solution to diseases that are historically treated medically or surgically. One such focus of research is the treatment of medically refractory epilepsy, which is traditionally approached from a surgical or interventional standpoint. Research shows that stem cell transplantation has potential to offer significant benefits to the epilepsy patient by reducing seizure frequency, intensity, and neurological deficits that often result from the condition. This review explores the basic science progress made on the topic of stem cells and epilepsy by focusing on experiments using animal models and highlighting the most recent developments from the last 4 years.
干细胞治疗领域发展迅速，有望为历史上采用药物或手术治疗的疾病提供另一种解决方案。其中一个研究重点是治疗药物难治性癫痫，传统上从手术或介入角度来处理这种疾病。研究表明，干细胞移植通过减少癫痫发作的频率、强度和由此产生的神经功能缺损，为癫痫患者带来了显著的益处。本综述通过关注使用动物模型的实验，探讨了干细胞与癫痫这一主题的基础科学进展，并强调了过去 4 年的最新进展。
