Univ Paris Est Créteil, INSERM, IMRB, Translational Neuropsychiatry, Créteil, F-94000, France.
Fondation FondaMental, Créteil, F-94000, France.
Epigenomics. 2023 Jan;15(1):21-38. doi: 10.2217/epi-2023-0017. Epub 2023 Mar 15.
The choice of efficient antipsychotic therapy for schizophrenia relies on a time-consuming trial-and-error approach, whereas the social and economic burdens of the disease call for faster alternatives. In a search for predictive biomarkers of antipsychotic response, blood methylomes of 28 patients were analyzed before and 4 weeks into risperidone therapy. Several CpGs exhibiting response-specific temporal dynamics were identified in otherwise temporally stable methylomes and noticeable global response-related differences were observed between good and bad responders. These were associated with genes involved in immunity, neurotransmission and neuronal development. Polymorphisms in many of these genes were previously linked with schizophrenia etiology and antipsychotic response. Antipsychotic response seems to be shaped by both stable and medication-induced methylation differences.
对于精神分裂症的有效抗精神病治疗的选择依赖于耗时的反复试验方法，而疾病的社会和经济负担需要更快的替代方法。在寻找抗精神病药物反应的预测生物标志物的过程中，对 28 名患者的血液甲基组在利培酮治疗前和 4 周后进行了分析。在其他时间稳定的甲基组中发现了几个表现出反应特异性时间动态的 CpG，并在良好和不良反应者之间观察到明显的与全局反应相关的差异。这些与涉及免疫、神经传递和神经元发育的基因有关。这些基因中的许多多态性先前与精神分裂症病因和抗精神病药物反应有关。抗精神病药物反应似乎是由稳定和药物诱导的甲基化差异共同形成的。
