Mooranian Armin, Ionescu Corina Mihaela, Wagle Susbin Raj, Kovacevic Bozica, Walker Daniel, Jones Melissa, Chester Jacqueline, Johnston Edan, Mikov Momir, Stankov Karmen, Elnashar Magdy, Al-Salami Hani
The Biotechnology & Drug Development Research Laboratory, Curtin Medical School & Curtin Health Innovation Research Institute, Curtin University, Bentley, Perth, Western Australia, 6102, Australia.
School of Pharmacy, University of Otago, Dunedin, Otago, New Zealand.
Ther Deliv. 2023 Jan;14(1):17-29. doi: 10.4155/tde-2022-0037. Epub 2023 Mar 15.
Major challenges to islet transplantation in Type 1 diabetes include host-inflammation, which results in failure to maintain survival and functions of transplanted islets. Therefore, this study investigated the applications of encapsulating the bile acid ursodeoxycholic acid (UDCA) with transplanted islets within improved nano-gel systems for Type 1 diabetes treatment. Islets were harvested from healthy mice, encapsulated using UDCA-nano gel and transplanted into the diabetic mice, while the control group was transplanted encapsulated islets without UDCA. The two groups' survival plot, blood glucose, and inflammation and bile acid profiles were analyzed. UDCA-nano gel enhanced survival, glycemia and normalized bile acids' profile, which suggests improved islets functions and potential adjunct treatment for insulin therapy.
1型糖尿病胰岛移植面临的主要挑战包括宿主炎症，这会导致移植胰岛无法维持存活和功能。因此，本研究探讨了在改良纳米凝胶系统中用胆汁酸熊去氧胆酸（UDCA）包裹移植胰岛在1型糖尿病治疗中的应用。从健康小鼠体内获取胰岛，用UDCA-纳米凝胶包裹后移植到糖尿病小鼠体内，而对照组移植的是未添加UDCA的包裹胰岛。分析了两组的存活曲线、血糖、炎症和胆汁酸谱。UDCA-纳米凝胶提高了胰岛的存活率、改善了血糖水平并使胆汁酸谱正常化，这表明其改善了胰岛功能，并且可能是胰岛素治疗的潜在辅助治疗方法。
