Department of Gynecologic Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis & Translational Research, Peking University Cancer Hospital & Institute, Beijing, China.
Future Oncol. 2023 Feb;19(5):397-408. doi: 10.2217/fon-2022-1061. Epub 2023 Mar 15.
The authors conducted a meta-analysis to determine the association between time-to-surgery (TTS) after neoadjuvant chemotherapy and patient outcomes in locally advanced gastric cancer. Electronic databases were searched to identify potential studies, in which the authors compared patient outcomes between those with TTS within 4 (and 6) weeks of completion of neoadjuvant chemotherapy and those after 4 (and 6) weeks. Six studies, including 1238 patients, were eligible for inclusion. Pooled data showed no significant differences in rates of pathological complete response, major pathological response, ypN0, complications, R0 resection and operative time between groups of longer TTS and shorter TTS. There was no statistically advantageous impact of prolonged TTS on pathological and surgical outcomes. Large, population-based studies are warranted.
作者进行了一项荟萃分析，以确定新辅助化疗后手术时间（TTS）与局部晚期胃癌患者结局之间的关系。作者检索电子数据库以确定潜在的研究，其中比较了新辅助化疗完成后 4 （和 6 ）周内 TTS 与 4 （和 6 ）周后 TTS 的患者结局。纳入了 6 项研究，共 1238 例患者。汇总数据显示，较长 TTS 组和较短 TTS 组之间在病理完全缓解率、主要病理缓解率、ypN0、并发症、R0 切除和手术时间方面无显著差异。TTS 延长对病理和手术结局没有统计学上的有利影响。需要进行大规模的基于人群的研究。
