鼻窦鼻腔恶性肿瘤的最新进展：诊断方式的进步。
Update on Sinonasal Tract Malignancies: Advances in Diagnostic Modalities.
机构信息
From the Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia. Gubbiotti is now located at the Department of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston.
出版信息
Arch Pathol Lab Med. 2024 Oct 1;148(10):1082-1091. doi: 10.5858/arpa.2022-0447-RA.
CONTEXT.—: Sinonasal tract malignancies are rare cancers with frequent morphologic overlap. Given the similar histologic profiles seen in many of these entities, they often present a diagnostic challenge to the practicing pathologist.
OBJECTIVE.—: To provide a streamlined algorithm using histologic clues, immunohistochemical profiles, and molecular assays to aid in diagnosis of these lesions.
DATA SOURCES.—: Sources were the World Health Organization Tumor Classification, literature review, and institutional experience.
CONCLUSIONS.—: Although many sinonasal tract malignancies show similar histology, distinct immunohistochemical and molecular profiles can help parse out differences, thereby facilitating diagnosis for the pathologist.
背景
鼻腔鼻窦肿瘤是罕见的癌症，具有频繁的形态学重叠。鉴于这些实体中许多具有相似的组织学特征，它们常常给临床病理学家带来诊断挑战。
目的
提供一种使用组织学线索、免疫组织化学特征和分子检测的简化算法，以帮助诊断这些病变。
数据来源
来源是世界卫生组织肿瘤分类、文献回顾和机构经验。
结论
尽管许多鼻腔鼻窦肿瘤显示出相似的组织学，但明确的免疫组织化学和分子特征可以帮助区分差异，从而为病理学家提供诊断帮助。
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