General Hospital Zabok, Zabok, Croatia.
Department of Neurology, Referral Center for Autonomic Nervous System Disorders, University Hospital Center Zagreb, Kišpatićeva 12, 10000, Zagreb, Croatia.
Wien Med Wochenschr. 2023 Sep;173(11-12):287-289. doi: 10.1007/s10354-023-01007-7. Epub 2023 Mar 15.
After 2 weeks of treatment, a woman with multiple sclerosis treated with dimethyl fumarate developed alopecia. Considering the adverse events, the therapy was discontinued, leading to alopecia regression during the next 3 months. Although the precise mechanism has not been completely elucidated, glutathione depletion or downregulation of aerobic glycolysis are considered to be potential reasons for hair loss induction. The incidence and mechanism of this uncommon adverse reaction to dimethyl fumarate should be further investigated.
在接受二甲基富马酸酯治疗 2 周后，1 名多发性硬化症女性患者出现脱发。考虑到不良事件，停止了治疗，导致接下来 3 个月内脱发逐渐恢复。尽管确切的机制尚未完全阐明，但谷胱甘肽耗竭或有氧糖酵解下调被认为是导致脱发的潜在原因。应该进一步研究二甲基富马酸酯这种罕见不良反应的发生率和机制。
