肺动脉高压吸入治疗：更新综述。
Pulmonary hypertension inhaled therapies: An updated review.
机构信息
Division of Pulmonary, Critical Care, & Sleep Medicine, Department of Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Assistant Professor of Medicine, Divisions of Cardiovascular Critical Care and Advanced Heart Failure, Heart and Vascular Institute, West Virginia University, Morgantown, WV 26506, United States.
出版信息
Am J Med Sci. 2023 Jul;366(1):3-15. doi: 10.1016/j.amjms.2023.03.002. Epub 2023 Mar 13.
Treatments of pulmonary hypertension (PH) continue to evolve with approval of new therapies. The currently FDA approved inhaled PH therapies include inhaled iloprost for group 1 pulmonary arterial hypertension (PAH), inhaled treprostinil solution and treprostinil dry powder inhaler for both group 1 PAH and group 3 PH associated with interstitial lung disease (PH-ILD). Inhaled treprostinil was recently approved for group 3 PH-ILD based on the results of INCREASE trial and the newer formulation of treprostinil dry powder that comes with a new inhaler was recently approved for both group 1 PAH and group 3 PH-ILD based on BREEZE study. The pipeline for inhaled PH therapies includes several promising molecules that can enrich the current PH therapeutic era and mitigate several systemic side effects by directly delivering the drug to the target organ. In this review article we summarize the evidence for the currently approved inhaled PAH/PH therapies, discuss the available inhalation devices, present a roadmap for successful treatment strategy, and present several inhaled PAH/PH therapies in the pipeline.
肺动脉高压（PH）的治疗方法不断发展，新疗法不断获得批准。目前美国食品和药物管理局（FDA）批准的吸入性 PH 治疗药物包括用于 1 型肺动脉高压（PAH）的吸入性伊洛前列素、用于 1 型 PAH 和与间质性肺疾病（PH-ILD）相关的 3 型 PH 的吸入性曲前列尼尔溶液和吸入性曲前列尼尔干粉吸入剂。基于 INCREASE 试验的结果和新的曲前列尼尔干粉制剂，吸入性曲前列尼尔最近被批准用于治疗 3 型 PH-ILD；基于 BREEZE 研究，新型干粉吸入器最近被批准用于治疗 1 型 PAH 和 3 型 PH-ILD。吸入性 PH 治疗药物的研发管线包括几种有前途的分子，这些分子可以丰富当前的 PH 治疗时代，并通过将药物直接输送到靶器官来减轻几种全身副作用。在这篇综述文章中，我们总结了目前批准的吸入性 PAH/PH 治疗方法的证据，讨论了现有的吸入装置，提出了成功治疗策略的路线图，并介绍了几种处于研发管线中的吸入性 PAH/PH 治疗方法。
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