Chen H, Zhu R F, Liao X T, Sun B Q
Department of Allergy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hunan Center for Drug Evaluation and Adverse Reaction Monitoring,Changsha 410013, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2023 Mar 6;57(3):333-340. doi: 10.3760/cma.j.cn112150-20220726-00758.
There are many types in food allergy, and the most common is mediated by IgE. Currently, the diagnosis of food allergy mainly relied on skin prick test and serum specific IgE of allergen extract, which can not identify cross-sensitization. Component-resolved diagnosis (CRD) can identify the major allergen components and cross-components of food allergens, which plays an important role in dietary guidance, prognosis monitoring and diagnosis of special types of IgE-mediated food allergy. This article enumerates clinical characteristics of the IgE-mediated common food allergies, such as milk, egg and seafood allergy, and special type of food allergy, such as cat pork syndrome, oral allergy syndrome, α-gal syndrome and food-dependent exercise-induced anaphylaxis, summarizes the advances of CRD in these types of IgE-mediated food allergy, in order to provide an evidence for the diagnosis, treatment and prevention of IgE-mediated food allergy.
食物过敏有多种类型，最常见的是由免疫球蛋白E（IgE）介导的。目前，食物过敏的诊断主要依靠皮肤点刺试验和过敏原提取物的血清特异性IgE检测，但这两种方法无法识别交叉致敏。组分分辨诊断（CRD）能够识别食物过敏原的主要过敏原成分和交叉成分，在饮食指导、预后监测以及特殊类型IgE介导的食物过敏诊断中发挥着重要作用。本文列举了IgE介导的常见食物过敏（如牛奶、鸡蛋和海鲜过敏）以及特殊类型食物过敏（如猫猪肉综合征、口腔过敏综合征、α-半乳糖综合征和食物依赖运动诱发的过敏反应）的临床特征，总结了CRD在这些类型IgE介导的食物过敏中的研究进展，以便为IgE介导的食物过敏的诊断、治疗和预防提供依据。
