Xu C Y, Li W T, Tian Y H
College of Environmental and Engineering, Donghua University, Shanghai 201620, China.
Women's Hospital School of Medicine Zhejiang University, Hangzhou 310006, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2023 Mar 6;57(3):362-370. doi: 10.3760/cma.j.cn112150-20220503-00435.
To investigate the correlation between the prenatal exposure of per-/polyfluoroalkyl substances (PFASs) and the neonatal outcome. A total of 506 maternal infant cohort samples were collected in Hangzhou, Zhejiang province from 2020 to 2021. The exposure levels of seven PFASs in maternal serum before delivery were detected by solid-phase extraction-ultra performance liquid chromatography tandem mass spectrometry. Multivariable linear regression model was used to analyze the influence of prenatal exposure of PFASs on birth weight, birth length and Apgar score. The maternal age, prenatal body mass index and gestation age were (31.3±4.3) years old, (26.7±3.2) kg/m and (265.0±28.3) days, respectively. The birth weight, birth length and scores of Apgar-1 and Apgar-5 were (3.1±0.8) kg, (49.3±2.9) cm, (9.88±0.47) points and (9.99±0.13) points, respectively. PFASs were widely distributed in maternal serum, with the highest concentration of (18.453±19.557) ng/ml, (6.756±9.379) ng/ml and (5.057±8.555) ng/ml for perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS) and 6∶2 chlorinated polyfluorinated ether sulfonate (Cl-PFESA), respectively. Maternal age, parity and delivery mode were associated with the exposure level of PFASs (<0.05). Subgroup analysis showed that PFOS had negative effects on birth weight (-0.958), birth length (-0.073) and Apgar-5 score (-0.288) for neonates in the low birth weight (LBW) group. 6∶2 Cl-PFESA and 8∶2 Cl-PFESA inhibited the birth weight (-0.926; -0.552) and length (-0.074; -0.045) of newborn in the LBW group. In addition, 4∶2 fluorotelomer sulfonate (FTS) was associated with increased birth weight (=0.111) and decreased Apgar-5 score (=-0.030) in the normal weight group. Prenatal exposure to PFASs is associated with birth weight, birth length and Apgar-5 score. It is necessary to continue to pay attention to the impact of PFASs on fetal growth and development through maternal-fetal transmission.
探讨全氟/多氟烷基物质（PFASs）产前暴露与新生儿结局之间的相关性。2020年至2021年在浙江省杭州市共收集了506例母婴队列样本。采用固相萃取-超高效液相色谱串联质谱法检测分娩前母血中7种PFASs的暴露水平。运用多变量线性回归模型分析PFASs产前暴露对出生体重、出生身长和阿氏评分的影响。母亲年龄、产前体重指数和孕周分别为（31.3±4.3）岁、（26.7±3.2）kg/m²和（265.0±28.3）天。出生体重、出生身长以及1分钟和5分钟阿氏评分分别为（3.1±0.8）kg、（49.3±2.9）cm、（9.88±0.47）分和（9.99±0.13）分。PFASs在母血中广泛分布，全氟辛酸（PFOA）、全氟辛烷磺酸（PFOS）和6∶2氯代多氟醚磺酸（Cl-PFESA）的最高浓度分别为（18.453±19.557）ng/ml、（6.756±9.379）ng/ml和（5.057±8.555）ng/ml。母亲年龄、产次和分娩方式与PFASs暴露水平相关（<0.05）。亚组分析显示，PFOS对低出生体重（LBW）组新生儿的出生体重（-0.958）、出生身长（-0.073）和5分钟阿氏评分（-0.288）有负面影响。6∶2 Cl-PFESA和8∶2 Cl-PFESA抑制了LBW组新生儿的出生体重（-0.926；-0.552）和身长（-0.074；-0.045）。此外，4∶2氟调聚物磺酸（FTS）与正常体重组新生儿出生体重增加（=0.111）和5分钟阿氏评分降低（=-0.030）有关。PFASs产前暴露与出生体重、出生身长和5分钟阿氏评分有关。有必要继续关注PFASs通过母婴传播对胎儿生长发育的影响。
