环孢菌素A的每个侧链对于跨脂质双层的高被动通透性并非必不可少。
Each side chain of cyclosporin A is not essential for high passive permeability across lipid bilayers.
作者信息
Ono Takahiro, Tabata Kazuhito V, Noji Hiroyuki, Morimoto Jumpei, Sando Shinsuke
机构信息
Department of Chemistry & Biotechnology, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 Japan
Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo 7-3-1 Hongo, Bunkyo-ku Tokyo 113-8656 Japan.
出版信息
RSC Adv. 2023 Mar 13;13(12):8394-8397. doi: 10.1039/d3ra01358h. eCollection 2023 Mar 8.
We compared the passive permeability of cyclosporin A (CsA) derivatives with side chain deletions across lipid bilayers. CsA maintained passive permeability after losing any one of the side chains, which suggests that the propensity of the backbone of CsA is an important component for high passive permeability.
我们比较了具有侧链缺失的环孢菌素A（CsA）衍生物跨脂质双层的被动通透性。CsA在失去任何一条侧链后仍保持被动通透性，这表明CsA主链的倾向是高被动通透性的重要组成部分。
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