卡什县记忆研究中的白质高信号临床评级、海马体评级及神经心理功能
Clinical Ratings of White Matter Hyperintensities, Hippocampal Ratings, and Neuropsychological Functioning from The Cache County Memory Study.
作者信息
Farrer T J, Bigler E D, Tsui-Caldwell Y H W, Abildskov T J, Tschanz J A T, Norton M C, Welsh-Bohmer K A
机构信息
Department of Psychiatry and Neurology, Duke University, Durham, NC.
Department of Psychology, Brigham Young University, Provo, UT, USA.
出版信息
JAR Life. 2022 Mar 21;11:9-13. doi: 10.14283/jarlife.2022.2. eCollection 2022.
OBJECTIVE
White matter burden and medial temporal atrophy are associated with cognitive health. A large epidemiological database, such as the Cache County Memory Study (CCMS), can provide additional insight into how visual clinical ratings of brain structural integrity predict cognition in older adults.
METHOD
We used the Scheltens Ratings Scale to quantify white matter lesion burden and medial temporal atrophy in the CCMS sample to determine if these qualitative markers are predictive of memory function. We performed clinical ratings of MRI scans across two ascertainment periods among 187 community-dwelling older adults and correlated these ratings with MMSE, CERAD memory performance, and general cognitive ability.
RESULTS
Higher Scheltens ratings measuring white matter and basal ganglia hyperintensities were associated with lower memory performance (r = 0.21). The strongest correlations were observed between medial temporal atrophy and general cognition performance (r = 0.32).
CONCLUSIONS
The current findings support previous research that the integrity of different regions of the brain correlate to function in a meaningful way.
目的
脑白质负荷和内侧颞叶萎缩与认知健康相关。大型流行病学数据库，如卡什县记忆研究（CCMS），可以提供更多关于脑结构完整性的视觉临床评分如何预测老年人认知的见解。
方法
我们使用谢尔滕斯评分量表对CCMS样本中的脑白质病变负荷和内侧颞叶萎缩进行量化，以确定这些定性指标是否能预测记忆功能。我们对187名社区居住的老年人在两个确定期内的MRI扫描进行了临床评分，并将这些评分与MMSE、CERAD记忆表现和一般认知能力进行了关联。
结果
测量脑白质和基底节高信号的谢尔滕斯评分越高，记忆表现越低（r = 0.21）。内侧颞叶萎缩与一般认知表现之间的相关性最强（r = 0.32）。
结论
目前的研究结果支持先前的研究，即大脑不同区域的完整性与功能以有意义的方式相关。
Zotero 插件