Berger J
Laboratory of Haematology, Research Institute for Pharmacy and Biochemistry, Pardubice-Rosice, Czechoslovakia.
Haematologia (Budap). 1987;20(3):171-8.
Treatment of adult rats of three age groups (8, 11 and 29 weeks) with haematotoxic doses of three different cytostatic agents (cyclophosphamide, 5-(2-dimethyl-aminoethoxy)-7-oxo-7H-benzo(c)fluorene, and lomustine) demonstrated a tendency to lower the sensitivity of elder animals to cytotoxic effects. The influence of age was especially distinct in changes of the reticulocyte or segmented neutrophil counts after all drugs tested. Changes in marrow nucleated erythroid cell counts were not significantly influenced by age. Reactions of other characteristics also depended on this factor but not following the administration of every drug.
用三种不同的细胞毒性药物（环磷酰胺、5-（2-二甲基氨基乙氧基）-7-氧代-7H-苯并[c]芴和洛莫司汀）的血液毒性剂量对三个年龄组（8周、11周和29周）的成年大鼠进行治疗，结果显示老年动物对细胞毒性作用的敏感性有降低的趋势。在所有测试药物之后，年龄的影响在网织红细胞或分叶中性粒细胞计数的变化中尤为明显。骨髓有核红细胞计数的变化不受年龄的显著影响。其他特征的反应也取决于这个因素，但并非在每种药物给药后都如此。
