Funakoshi Mai, Nakai Go, Yamada Takashi, Ohmichi Masahide, Yamamoto Kazuhiro, Osuga Keigo
Department of Diagnostic Radiology, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.
Department of Pathology, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki City, Osaka 569-8686, Japan.
Radiol Case Rep. 2023 Mar 3;18(5):1767-1771. doi: 10.1016/j.radcr.2023.02.016. eCollection 2023 May.
Although imaging studies are not typically performed for clinical diagnosis of cervicitis, in this case magnetic resonance imaging (MRI) was performed because a lesion with a tumor-like gross appearance was found in the uterine cervix. We present a case of cervicitis in which clinical, imaging and pathological features overlapped with those of gastric-type mucinous adenocarcinoma (GAS). The patient, a 30-year-old woman, was referred to a gynecologist with a complaint of watery vaginal discharge. On visual examination, the uterine cervix was irregularly enlarged and bled easily, suggesting cervical cancer. The next day, the patient had a fever of 39°C and blisters appeared on her vulva due to herpes simplex virus type II infection. MRI showed a diffusely enlarged cervix with poorly marginated high signal intensity on T2-weighted imaging (WI) and apparent diffusion coefficient map as well as strong enhancement on contrast-enhanced T1WI, which are findings consistent with GAS. Although a punch biopsy showed only mild atypia of the cervical glands, this was not enough to completely rule out GAS. Consequently, laser conization of the lesion was performed for definitive diagnosis, and the diagnosis of cervicitis was made. Acute cervicitis can be difficult to differentiate from GAS based on symptoms, results of cervical biopsy and MR imaging because of their overlapping features. Even when a patient presents with a lesion with tumor-like gross appearance, acute cervicitis should be included in the differential diagnosis if the result of cervical biopsy is negative, especially when accompanied by infection-like fever.
虽然影像学检查通常不用于宫颈炎的临床诊断,但在该病例中,由于在子宫颈发现了具有肿瘤样大体外观的病变,因此进行了磁共振成像(MRI)检查。我们报告一例宫颈炎病例,其临床、影像学和病理学特征与胃型黏液腺癌(GAS)重叠。患者为一名30岁女性,因水样白带增多就诊于妇科医生。肉眼检查发现子宫颈不规则增大且易出血,提示宫颈癌。第二天,患者因Ⅱ型单纯疱疹病毒感染出现发热至39°C,外阴出现水疱。MRI显示子宫颈弥漫性增大,在T2加权成像(WI)和表观扩散系数图上边界不清的高信号强度,以及在对比增强T1WI上有明显强化,这些表现与GAS一致。尽管穿刺活检仅显示宫颈腺体轻度异型性,但这不足以完全排除GAS。因此,为明确诊断对病变进行了激光锥切术,最终诊断为宫颈炎。由于急性宫颈炎和GAS的特征重叠,基于症状、宫颈活检结果和磁共振成像很难将两者区分开来。即使患者出现具有肿瘤样大体外观的病变,如果宫颈活检结果为阴性,尤其是伴有感染样发热时,急性宫颈炎也应列入鉴别诊断。