Surya Gavini, Ajit Nimmagadda, Priya Rallapeta Ramya, Hemalatha Dhamarcherla S, Devi Bodagala Vijayalakshmi, Kalawat Tekchand
Department of Nuclear Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
Department of Radiology, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.
World J Nucl Med. 2022 Sep 9;22(1):36-39. doi: 10.1055/s-0042-1757254. eCollection 2023 Mar.
Leptomeningeal carcinomatosis is a manifestation in which tumor cells migrate into meninges. Breast carcinoma presenting with leptomeningeal metastases is a rare phenomenon that can occur in an isolated form as well as with coexistent parenchymal brain metastases. The gold standard for diagnosis is cerebrospinal fluid analysis, while contrast-enhanced magnetic resonance imaging is the most commonly used imaging modality. Nuclear medicine imaging with flourine-18-fluorodeoxyglucose positron emission tomography/computed tomography has proved to be useful in detecting leptomeningeal metastases and, at times, even before anatomical changes occur. Here, we present a case of breast carcinoma presenting with both pachymeningeal and leptomeningeal metastases 10 years after treatment.
柔脑膜癌病是肿瘤细胞迁移至脑膜的一种表现形式。出现柔脑膜转移的乳腺癌是一种罕见现象，可单独发生，也可与脑实质转移并存。诊断的金标准是脑脊液分析，而增强磁共振成像则是最常用的影像学检查方式。氟-18-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描的核医学成像已被证明在检测柔脑膜转移方面很有用，有时甚至在解剖学变化出现之前就能检测到。在此，我们报告一例乳腺癌患者在治疗10年后出现硬脑膜和柔脑膜转移的病例。
