微生物学评论提示对无症状菌尿症抗生素使用的影响：一项前后准实验研究。
Effect of microbiology comment nudging on antibiotic use in asymptomatic bacteriuria: A before-and-after quasi-experimental study.
机构信息
Huntsville Hospital, Department of Pharmacy, Huntsville, Alabama.
TriStar Centennial Medical Center, Nashville, Tennessee.
出版信息
Infect Control Hosp Epidemiol. 2023 Sep;44(9):1391-1395. doi: 10.1017/ice.2022.272. Epub 2023 Mar 16.
OBJECTIVE
To describe the effect of a microbiology comment nudge on antibiotic use for asymptomatic bacteriuria (ASB).
DESIGN
Single-center, before-and-after, quasi-experimental study.
SETTING
Community-based, public, not-for-profit teaching hospital in the southeastern United States.
PARTICIPANTS
Adult inpatients with a positive urine culture and the absence of urinary tract infection signs and symptoms.
INTERVENTION
Implementation of a microbiology comment nudge on urine cultures.
RESULTS
In total, 204 patients were included in the study. Antibiotics were less likely to be continued beyond 72 hours in the postimplementation group: 57 (55%) of 104 versus 38 (38%) of 100 ( = .016). They were less likely to have antibiotics continued beyond 48 hours: 60 (58%) of 104 versus 43 (43%) of 100 ( = .036). They were also less likely to have antibiotics prescribed at discharge 35 (34%) of 104 versus 20 (20%) of 100 ( = .028). In addition, they had fewer total antibiotic days of therapy: 4 (IQR, 1-6) versus 1 (IQR, 0-6) ( = .022).
CONCLUSION
Microbiology comment nudging may contribute to less antibiotic utilization in patients with ASB.
目的
描述微生物评论提示对无症状性菌尿（ASB）抗生素使用的影响。
设计
单中心、前后、准实验研究。
地点
美国东南部的社区性、公立、非营利性教学医院。
参与者
尿液培养阳性且无尿路感染体征和症状的成年住院患者。
干预措施
对尿液培养实施微生物评论提示。
结果
共有 204 例患者纳入研究。在实施后组中，抗生素持续使用超过 72 小时的可能性降低：104 例中有 57 例（55%），而 100 例中有 38 例（38%）（ =.016）。抗生素持续使用超过 48 小时的可能性降低：104 例中有 60 例（58%），而 100 例中有 43 例（43%）（ =.036）。抗生素在出院时开具的可能性也降低：104 例中有 35 例（34%），而 100 例中有 20 例（20%）（ =.028）。此外，他们的抗生素治疗总天数更少：4 天（IQR，1-6）与 1 天（IQR，0-6）（ =.022）。
结论
微生物评论提示可能有助于减少 ASB 患者的抗生素使用。
Zotero 插件