Darmadi Darmadi, Pakpahan Cennikon, Rezano Andri, Pasaribu Wanly Syahrizal, Ahmad Herwindo, Lubis Adriansyah, Supardi Supardi
Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan.
Andrology Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya; Department of Biomedical Sciences, Faculty of Medicine, Universitas Airlangga, Surabaya.
Arch Ital Urol Androl. 2023 Feb 22;95(1):11100. doi: 10.4081/aiua.2023.11100.
Hypogonadism and inflammato-ry bowel disease (IBD) are often associated. This association may influence sexual and reproductive function in IBD, including sperm profile and sex steroid hormones.
This study included 59 IBD patients diagnosed with ulcerative colitis type IBD. Anamnesis was carried out regarding the history of the disease, along with a history of rectal bleeding. Evaluation proceeded with sperm and hormone examination if the patient agreed.
Progressive motility sperm, immotile sperm, and normal sperm were found to be significantly different between the rectal bleeding groups. In grade 3 (more significant bleeding) progressive sperm (24.81 ± 5.85, p < 0.0001) and normal sperm (6.33 ± 12.56, p = 0.0003) rates tended to be lower, while immotile sperm tended to be higher (44.48 ± 11.21, p < 0.0001). Testosterone and free testosterone levels were also reported to be significantly different between groups, where grade 3 had lower levels 255.9 ± 30.08, p = 0.014 and 4.645 ± 0.5, p = 0.002 respectively.
Our study shows that the degree of rectal bleeding influences sperm motility and morphology, as well as testosterone and free testosterone levels. These results can concern managing IBD patients to fulfill reproductive health care.
性腺功能减退与炎症性肠病（IBD）常有关联。这种关联可能会影响IBD患者的性和生殖功能，包括精子参数和性类固醇激素。
本研究纳入了59例诊断为IBD溃疡性结肠炎的患者。收集了疾病史以及直肠出血史。如果患者同意，则进行精子和激素检查。
直肠出血组之间的进行性运动精子、不动精子和正常精子存在显著差异。在3级（出血更严重）中，进行性精子（24.81±5.85，p<0.0001）和正常精子（6.33±12.56，p = 0.0003）的比例往往较低，而不动精子往往较高（44.48±11.21，p<0.0001）。据报道，各组之间的睾酮和游离睾酮水平也存在显著差异，3级的水平较低，分别为255.9±30.08，p = 0.014和4.645±0.5，p = 0.002。
我们的研究表明，直肠出血程度会影响精子活力和形态，以及睾酮和游离睾酮水平。这些结果可能与管理IBD患者以实现生殖健康护理有关。
