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从CRISPR角度看草甸田鼠中的催产素受体

A CRISPR perspective of the oxytocin receptor in prairie voles.

作者信息

Rajamani Keerthi Thirtamara, Harony-Nicolas Hala

机构信息

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Mindich Child Health and Development Institute at the Icahn School of Medicine at Mount Sinai, New York, NY, USA.

出版信息

Neuron. 2023 Mar 15;111(6):755-756. doi: 10.1016/j.neuron.2023.02.011.

Abstract

The oxytocin receptor has long been considered critical for social bonding and parenting in prairie voles. In this issue of Neuron, Berendzen et al. show that oxytocin receptor-null prairie voles display normal bonding and parental behaviors, thus challenging the prevailing understanding of the receptor's role in these behaviors.

摘要

长期以来,催产素受体一直被认为对草原田鼠的社交联系和养育行为至关重要。在本期《神经元》杂志中,贝伦岑等人表明,缺乏催产素受体的草原田鼠表现出正常的联系和养育行为,从而挑战了人们对该受体在这些行为中所起作用的普遍理解。

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