Department of Orthopaedics surgery, West China Hospital, Sichuan University, Chengdu, PR China.
J Arthroplasty. 2023 Sep;38(9):1760-1766. doi: 10.1016/j.arth.2023.03.012. Epub 2023 Mar 14.
Whether artificial bone provides comparable outcomes to autogenous bone has not been determined for osteonecrosis of the femoral head (ONFH). This study was conducted to compare the clinical outcomes of autogenous and artificial bone grafting (demineralized bone matrix/calcium sulfate [DBM/CaS]) through a modified lightbulb technique by percutaneous femoral neck-head fenestration for treating precollapse ONFH.
A total of 73 Association Research Circulation Osseous Stage Ⅱ ONFH patients (81 hips) who had a mean follow-up of 61 months (range, 52 to 74) were included in this retrospective study. Among them were 40 hips treated with autogenous bone and 41 hips treated with DBM/CaS grafting through the percutaneous femoral neck-head fenestration. The Harris scores, radiographic progressions, clinical success rates, and survival analyses were analyzed.
At final follow-up, the mean Harris score was 80 points (range, 63 to 92) in the DBM/CaS group and 76 points (range, 69 to 91) in the autogenous bone group (P = .751). The radiographic progression rate was 29.9% in the DBM/CaS group, without significant difference from the autogenous bone group, which was 37.5% (P = .43). About 73.2% of patients in the DBM/CaS group and 75% in the autologous bone group avoided a total hip arthroplasty (P = .85). Survival analysis for femoral head protection revealed similar outcomes between the 2 groups (P > .05).
Percutaneous femoral neck-head fenestration combined with artificial bone (DBM/CaS) grafting had comparable clinical outcomes to autologous bone grafting on preventing femoral head collapse and rescuing THA at a mean of 61-month follow-up for treating early ONFH.
对于股骨头坏死(ONFH),人工骨是否能提供与自体骨相当的结果尚不确定。本研究通过经皮股骨颈-股骨头开窗改良灯泡技术,比较了自体骨和人工骨(脱钙骨基质/硫酸钙[DBM/CaS])移植治疗早期 ONFH 的临床结果。
本回顾性研究共纳入 73 例(81 髋)经 Association Research Circulation Osseous 分期为Ⅱ期的 ONFH 患者,平均随访 61 个月(52~74 个月)。其中 40 髋采用自体骨移植,41 髋采用经皮股骨颈-股骨头开窗 DBM/CaS 移植。分析了 Harris 评分、影像学进展、临床成功率和生存分析。
末次随访时,DBM/CaS 组的平均 Harris 评分为 80 分(6392 分),自体骨组为 76 分(6991 分)(P=.751)。DBM/CaS 组的影像学进展率为 29.9%,与自体骨组的 37.5%无显著差异(P=.43)。DBM/CaS 组约 73.2%的患者和自体骨组 75%的患者避免了全髋关节置换(P=.85)。股骨头保护的生存分析显示两组结果相似(P>.05)。
经皮股骨颈-股骨头开窗联合人工骨(DBM/CaS)移植在预防股骨头塌陷和挽救 THA 方面与自体骨移植具有相当的临床效果,平均随访 61 个月可治疗早期 ONFH。