Weeks J R
Acta Biol Med Ger. 1978;37(5-6):707-14.
Prostacyclin is a new prostaglandin first demonstrated as a product of arterial microsomes and prostaglandin endoperoxide intermediates. The potential to form prostacyclin has now been demonstrated in many organs. It inhibits platelet aggregation, inhibits gastric acid secretion, stimulates the monkey but not the rat uterus in vivo, is a bronchodilator, is a vasodepressor on both systemic and pulmonary circulation, increases cardiac output and markedly decreases peripheral resistance. It reduced progesterone in pregnant hamsters but is not luteolytic in non-pregnant monkeys. In rats, i. v. infusion of 0.56 but not 1 mg/kg/day was tolerated without overt central nervous system depression. The depressor effect of i. v. infusions of prostacyclin in anesthetized rats was partially antagonized by a pressor reaction eliminated by nephrectomy, an effect not seen during infusions of prostaglandin.
前列环素是一种新的前列腺素，最初被证明是动脉微粒体和前列腺素内过氧化物中间体的产物。现在已经在许多器官中证实了形成前列环素的可能性。它抑制血小板聚集，抑制胃酸分泌，在体内刺激猴子宫但不刺激大鼠子宫，是一种支气管扩张剂，对体循环和肺循环均有血管降压作用，增加心输出量并显著降低外周阻力。它能降低怀孕仓鼠体内的孕酮，但对未怀孕的猴子没有溶黄体作用。在大鼠中，静脉输注0.56mg/kg/天可耐受，而输注1mg/kg/天则不能耐受，且无明显中枢神经系统抑制。在麻醉大鼠中，静脉输注前列环素的降压作用部分被肾切除消除的升压反应所拮抗，而在输注前列腺素期间未观察到这种效应。
