Fujii M, Fujii T, Saito K, Takahashi N, Yoshikumi C, Kakuchi J, Kawai Y
Biomedical Research Laboratories, Kureha Chemical Industry Co., Tokyo, Japan.
Immunol Lett. 1987 Aug;15(4):347-51. doi: 10.1016/0165-2478(87)90140-4.
The role of an immunosuppressive substance (IS), which is increased in the serum of tumor-bearing animals, was examined in rats. IS isolated from cancerous ascites fluid of rats was administered to Walker 256 tumor-bearing rats to examine changes in the serum level of IS, tumor growth and survival rate. PSK, an immunomodulator, was also administered. Serum IS increased with tumor growth. The administration of IS to tumor-transplanted rats caused the tumor to grow and shortened the animals' survival time. The administration of PSK, however, inhibited the increase in serum level of IS, resulting in the suppression of tumor growth and a prolongation of survival time. The findings suggested that IS is a useful parameter for predicting not only tumor growth but also the therapeutic effect of immunomodulators such as PSK.
在大鼠中研究了一种免疫抑制物质（IS）的作用，该物质在荷瘤动物血清中含量升高。将从大鼠癌性腹水液中分离出的IS给予荷Walker 256肿瘤的大鼠，以检测血清中IS水平的变化、肿瘤生长情况和存活率。还给予了免疫调节剂PSK。血清IS水平随肿瘤生长而升高。给肿瘤移植大鼠注射IS会导致肿瘤生长，并缩短动物的存活时间。然而，注射PSK可抑制血清IS水平的升高，从而抑制肿瘤生长并延长存活时间。这些发现表明，IS不仅是预测肿瘤生长的有用参数，也是预测PSK等免疫调节剂治疗效果的有用参数。
