Department of Endocrinology, Key Laboratory of Endocrinology, National Commission of Health, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Endocrinol (Lausanne). 2023 Feb 28;14:1096950. doi: 10.3389/fendo.2023.1096950. eCollection 2023.
Irisin plays a role in bone-muscle crosstalk, but the relationship between the serum irisin level and bone microarchitecture remains unknown.
This study aimed to investigate the relationships between serum irisin level and fall risk, muscle strength, bone mineral density (BMD), and bone microarchitecture among Chinese postmenopausal women.
In all 138 postmenopausal women, handgrip strength, short physical performance battery (SPPB), and the timed up-and-go test were performed to evaluate muscle strength, physical performance, and fall risk, respectively. The serum irisin was measured. High-resolution peripheral quantitative computed tomography (HR-pQCT) was performed to acquire volumetric BMD and bone microarchitecture. Bivariate analysis was used to explore relationships between serum irisin level and muscle strength and HR-pQCT parameters. Univariate and multivariate linear regression analyses were performed to determine associations between serum irisin level and vBMD and cortical porosity (Ct.Po).
All participants had a median serum irisin level of 3.91 μg/ml. Participants with high fall risk had significantly lower serum irisin levels than those with low fall risk (2.22 μg/ml vs. 4.16 μg/ml, p=0.024). Irisin level was positively related to handgrip strength (rs=0.185, p=0.030) and SPPB performance. In univariate linear regression, serum irisin level was positively associated with cortical volumetric BMD (Ct.vBMD, radius: standardized β=0.184, p=0.031; tibia: standardized β=0.242, p=0.004), but it had no significant associations with Ct.vBMD after multivariate adjustment. After adjusting by age, height, serum sclerostin level, and body fat ratio, only Ct.Po at the distal radius had a significantly negative association with serum irisin level (standardized β=-0.276, p=0.003).
Postmenopausal women with lower serum irisin levels have a higher fall risk, weaker muscle strength, and higher cortical porosity. Moreover, serum irisin level has a positive association with Ct.vBMD, but it is affected by factors such as age.
鸢尾素在骨-肌串扰中发挥作用，但血清鸢尾素水平与骨微观结构之间的关系尚不清楚。
本研究旨在探讨中国绝经后妇女血清鸢尾素水平与跌倒风险、肌肉力量、骨密度（BMD）和骨微观结构之间的关系。
共纳入 138 名绝经后妇女，分别采用握力、短体性能电池（SPPB）和计时起立行走测试评估肌肉力量、身体机能和跌倒风险，检测血清鸢尾素水平，采用高分辨率外周定量计算机断层扫描（HR-pQCT）获取容积 BMD 和骨微观结构。采用双变量分析探讨血清鸢尾素水平与肌肉力量和 HR-pQCT 参数之间的关系。采用单变量和多变量线性回归分析血清鸢尾素水平与 vBMD 和皮质孔隙率（Ct.Po）之间的关联。
所有参与者的血清鸢尾素水平中位数为 3.91μg/ml。跌倒风险高的参与者血清鸢尾素水平显著低于跌倒风险低的参与者（2.22μg/ml 比 4.16μg/ml，p=0.024）。鸢尾素水平与握力（rs=0.185，p=0.030）和 SPPB 表现呈正相关。在单变量线性回归中，血清鸢尾素水平与皮质容积 BMD（桡骨：标准化β=0.184，p=0.031；胫骨：标准化β=0.242，p=0.004）呈正相关，但经多变量调整后与 Ct.vBMD 无显著关联。在校正年龄、身高、血清硬化素水平和体脂比后，仅桡骨远端的 Ct.Po 与血清鸢尾素水平呈显著负相关（标准化β=-0.276，p=0.003）。
血清鸢尾素水平较低的绝经后妇女跌倒风险较高、肌肉力量较弱、皮质孔隙率较高。此外，血清鸢尾素水平与 Ct.vBMD 呈正相关，但受年龄等因素的影响。
