de Freitas Ricardo Miguel Costa, da Silva Filho Mauricio Ricardo Moreira, Belon Alessandro Rodrigo, Jeng Brasil Chian Ping, Mayrink Denilson, Caldas José Guilherme Mendes Pereira
Department of Radiology, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
Instituto do Câncer do Estado de São Paulo (Icesp), São Paulo, SP, Brazil.
Radiol Bras. 2023 Jan-Feb;56(1):21-26. doi: 10.1590/0100-3984.2022.0054.
To evaluate acute and chronic changes seen on angiographic and histopathological studies of porcine rete mirabile, comparing those treated with the Menox liquid embolic system (LES) and those treated with the Onyx LES.
Five pigs, each weighing approximately 35 kg, were submitted to rete mirabile embolization under general anesthesia and fluoroscopic guidance, with the Menox LES or Onyx LES. Four animals were treated with the Menox LES and underwent cerebral angiography, followed by euthanasia, at 1, 30, 60, and 90 days after embolization. One animal was treated with the Onyx LES underwent the same procedures at 30 days after embolization. In a subsequent histopathological analysis, we compared the Menox LES and Onyx LES in terms of the acute and chronic changes observed.
We observed no significant changes in blood pressure, heart rate, or electrocardiographic parameters that could be attributed to the super-selective infusion of dimethyl sulfoxide or the Menox embolic agent. Fluoroscopy showed adequate material opacity, appropriate progression to the center of the rete mirabile and complete unilateral embolization. Microcatheters were uneventfully detached from the embolized nidus. We observed mild to moderate intravascular and extravascular inflammatory responses, without histological evidence of necrotizing arteritis. There were no adverse neurovascular events.
The Menox LES appears to be safe and effective, as well as being apparently equivalent to the Onyx LES in terms of the postprocedure angiographic and histopathological findings.
评估猪奇网血管造影和组织病理学研究中观察到的急性和慢性变化，比较使用美诺克斯液体栓塞系统（LES）治疗的猪和使用欧乃派克LES治疗的猪。
五只体重约35千克的猪在全身麻醉和透视引导下，使用美诺克斯LES或欧乃派克LES进行奇网栓塞。四只动物接受美诺克斯LES治疗，并在栓塞后1天、30天、60天和90天进行脑血管造影，随后实施安乐死。一只动物接受欧乃派克LES治疗，在栓塞后30天进行相同操作。在随后的组织病理学分析中，我们比较了美诺克斯LES和欧乃派克LES在观察到的急性和慢性变化方面的情况。
我们观察到血压、心率或心电图参数没有显著变化，这些变化不能归因于二甲亚砜或美诺克斯栓塞剂的超选择性注入。透视显示材料不透明度合适，向奇网中心的推进适当，并且单侧完全栓塞。微导管顺利地从栓塞病灶中分离。我们观察到轻度至中度的血管内和血管外炎症反应，没有坏死性动脉炎的组织学证据。没有不良神经血管事件。
美诺克斯LES似乎是安全有效的，并且在术后血管造影和组织病理学结果方面显然与欧乃派克LES相当。
