Wang Yuan, Yang Jing
Department of Pathology, Jinzhou Medical University, Jinzhou 121001, Liaoning Province, China.
World J Clin Cases. 2023 Mar 6;11(7):1642-1649. doi: 10.12998/wjcc.v11.i7.1642.
Extragonadal yolk sac tumors (YSTs) are rare, with only a low reported tumor occurrence outside the gonads locally and abroad. Extragonadal YSTs are usually a diagnostic challenge, because they are infrequent, but also because a thoughtful and detailed differential diagnostic process must be performed.
Here we present a case of an abdominal wall YST in a 20-year-old woman admitted with a tumor in the lower abdomen close to the umbilicus. The tumorectomy was performed. The histological examination revealed characteristic findings such as Schiller-Duval bodies, loose reticular structures, papillary structures, and eosinophilic globules. According to the immunohistochemical staining, the tumor tissue was positive for broad-spectrum cytokeratin, Spalt-like transcription factor 4, glypican-3, CD117, and epithelial membrane antigen. Based on the clinical information, histological features, and immunohistochemical staining profile, the tumor was diagnosed as a YST present in the abdominal wall.
Based on the clinical information, histological features, and immunohistochemical staining profile described above, the tumor was diagnosed as a primary YST in the abdominal wall.
性腺外卵黄囊瘤(YSTs)较为罕见,国内外报道的性腺外肿瘤发生率均较低。性腺外YSTs通常是诊断难题,这不仅是因为其罕见,还因为必须进行全面且细致的鉴别诊断过程。
在此,我们报告一例20岁女性腹壁YST病例,该患者因下腹部靠近脐部的肿瘤入院。进行了肿瘤切除术。组织学检查发现了特征性表现,如席勒-杜瓦尔小体、疏松网状结构、乳头结构和嗜酸性小球。根据免疫组化染色,肿瘤组织广谱细胞角蛋白、类Spalt转录因子4、磷脂酰肌醇蛋白聚糖-3、CD117和上皮膜抗原呈阳性。基于临床信息、组织学特征和免疫组化染色结果,该肿瘤被诊断为腹壁YST。
基于上述临床信息、组织学特征和免疫组化染色结果,该肿瘤被诊断为腹壁原发性YST。