Atypical polypoid adenomyoma of the uterus associated with Turner's syndrome. A report of three cases, including a review of "estrogen-associated" endometrial neoplasms and neoplasms associated with Turner's syndrome.

The clinical and pathological features of three atypical polypoid adenomyomas of the uterus that were associated with Turner's syndrome are described. The patients, at least two of whom had been on long-term exogenous estrogens, were in their third decade and presented with abnormal vaginal bleeding. In two cases an exophytic mass protruded through the external os and clinically suggested a malignant tumor. The histological (and in one case, the ultrastructural) findings were similar to those of previously described cases of atypical polypoid adenomyoma. The clinical findings in these cases suggest that some atypical polypoid adenomyomas may be a complication of prolonged estrogenic stimulation. The association between Turner's syndrome and other gynecological neoplasms is reviewed.