MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & Key Laboratory of Micro-systems and Micro-structures, Ministry of Education, Harbin Institute of Technology, Harbin 150001, China.
Key Laboratory of Materials Physics of Ministry of Education, School of Physics and Microelectronics, Zhengzhou University, Zhengzhou 450052, China.
Nano Lett. 2023 Apr 12;23(7):2862-2869. doi: 10.1021/acs.nanolett.3c00190. Epub 2023 Mar 16.
Lifetime-based NIR luminescent nanothermometry is ideally suited for temperature detection in living cells and in vivo, but the thermal sensitivity () modulation remains elusive. Herein, a thorough investigation is performed to unveil the shell effect on lifetime-based by finely controlling the shell thickness of lanthanide-doped core-shell-shell nanoparticles. Owing to the space-dependent energy transfer and back energy transfer between Nd and Yb as well as the energy migration to surface quenchers, both active and inert shells can regulate the thermal-dependent nonradiative decays and NIR luminescence lifetime of Yb, which in turn modulates the from 0.56% to 1.54% °C. After poly(acrylic acid) modification of the optimal architecture, the tiny nanoprobes possess robust stability to fluctuations in the microenvironment, which enables accurate temperature mapping of inflammation in the internal liver organ of living mouse. This work will provide new insights for optimizing and guidance for precise temperature measurements in vivo.
基于寿命的近红外发光纳米温度计非常适合用于活细胞和体内的温度检测，但热灵敏度（）调制仍然难以实现。在此，通过精细控制掺杂镧系元素的核壳壳纳米粒子的壳层厚度，对基于寿命的进行了深入研究，以揭示壳层效应对其的影响。由于 Nd 和 Yb 之间的能量转移和反向能量转移以及能量向表面猝灭剂的迁移，活性壳层和惰性壳层都可以调节 Yb 的热依赖性非辐射衰减和近红外发光寿命，从而使调制。经最佳结构的聚（丙烯酸）修饰后，微小的纳米探针具有对微环境波动的强稳定性，从而能够对活体小鼠内部肝脏炎症进行准确的温度测绘。这项工作将为优化提供新的见解，并为体内精确温度测量提供指导。
