遗传多态性对中国肝移植受者他克莫司谷浓度的影响。
Impact of genetic polymorphisms on tacrolimus trough blood concentration in Chinese liver transplant recipients.
机构信息
Department of Medical Genetics, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, Guangdong, China.
Division of Hepatobiliopancreatic Surgery, Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, Guangdong, China.
出版信息
Pharmacogenomics. 2023 Mar;24(4):207-217. doi: 10.2217/pgs-2022-0180. Epub 2023 Mar 17.
The aim of this study was to analyze the effects of various genetic polymorphisms and clinical factors on tacrolimus (TAC) concentration in the convalescence period (CP) and stabilization period (SP) post-liver transplantation. A total of 13 SNPs were genotyped in 97 Chinese liver transplant recipients. Associations between SNPs and TAC trough blood concentration/dose ratio (C/D) were analyzed using different genetic models in both CP and SP. Only five SNPs were significantly associated with TAC log (C/D) in the CP, and none showed a significant association in the SP. We identified rs15524 (), rs9200 (), albumin and creatinine as independent predictors of TAC C/D in the CP. Furthermore, a final model in the CP explained a total of 30.5% TAC variation. Our study results suggest that in the early stages post-transplantation surgery, recipients' genetic and clinical factors exert a short-term impact on TAC metabolism that gradually decreases with time.
本研究旨在分析各种遗传多态性和临床因素对肝移植后恢复期（CP）和稳定期（SP）他克莫司（TAC）浓度的影响。对 97 例中国肝移植受者进行了 13 个 SNP 的基因分型。在 CP 和 SP 中，使用不同的遗传模型分析 SNP 与 TAC 谷浓度/剂量比（C/D）之间的关系。只有 5 个 SNP 在 CP 中与 TAC 对数（C/D）显著相关，而在 SP 中均无显著相关性。我们发现 rs15524（）、rs9200（）、白蛋白和肌酐是 CP 中 TAC C/D 的独立预测因子。此外，CP 中的最终模型共解释了 30.5%的 TAC 变异。我们的研究结果表明，在移植手术后的早期阶段，受者的遗传和临床因素对 TAC 代谢产生短期影响，随着时间的推移这种影响逐渐减弱。
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