晚期宫颈癌全身炎症和凝血生物标志物分析：预后和预测意义。
Analysis of systemic inflammatory and coagulation biomarkers in advanced cervical cancer: Prognostic and predictive significance.
机构信息
Department of Gynecology, Weifang People's Hospital, Weifang, China.
Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, China.
出版信息
Int J Biol Markers. 2023 Jun;38(2):133-138. doi: 10.1177/03936155231163599. Epub 2023 Mar 16.
OBJECTIVE
Peripheral systemic inflammatory, nutritional, and coagulation biomarkers have prognostic and predictive value in various malignancies. We evaluated the prognostic and predictive roles of systemic inflammatory, nutritional, and coagulation biomarkers in the circulating blood of patients with advanced cervical cancer.
METHODS
A retrospective study of 795 patients with cervical cancer who received concurrent chemoradiation therapy was performed. Overall survival was evaluated by the Kaplan-Meier estimator. Univariate and multivariate Cox regression models were used to determine prognostic factors associated with overall survival.
RESULTS
The median follow-up time was 76 months. In the univariate analysis, overall survival showed positive prognostic value in patients with a platelet-to-lymphocyte ratio (PLR) <164.29 ( = 0.010), and a plasma fibrinogen (FIB) level <4 g/L( = 0.012). In the multivariate analysis, the PLR ( = 0.036), and FIB level ( = 0.047) maintained their significance for overall survival. Therefore, the PLR and FIB levels are independent prognostic factors in patients with advanced cervical cancer.
CONCLUSIONS
Systemic inflammatory and coagulation biomarkers could help to understand survival differences in the clinical treatment of advanced cervical cancer. The PLR and FIB levels are independent prognostic factors of poor survival in patients with advanced cervical cancer.
目的
外周全身性炎症、营养和凝血生物标志物在各种恶性肿瘤中具有预后和预测价值。我们评估了全身性炎症、营养和凝血生物标志物在晚期宫颈癌患者循环血液中的预后和预测作用。
方法
对 795 名接受同期放化疗的宫颈癌患者进行了回顾性研究。采用 Kaplan-Meier 估计法评估总生存率。采用单因素和多因素 Cox 回归模型确定与总生存率相关的预后因素。
结果
中位随访时间为 76 个月。在单因素分析中，血小板与淋巴细胞比值（PLR）<164.29（=0.010）和血浆纤维蛋白原（FIB）水平<4 g/L（=0.012）的患者总生存率呈正预后价值。在多因素分析中，PLR（=0.036）和 FIB 水平（=0.047）仍然是总生存率的独立预后因素。因此，PLR 和 FIB 水平是晚期宫颈癌患者的独立预后因素。
结论
全身性炎症和凝血生物标志物有助于了解晚期宫颈癌临床治疗中的生存差异。PLR 和 FIB 水平是晚期宫颈癌患者生存不良的独立预后因素。
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