Acupunture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Curr HIV Res. 2023;21(2):91-98. doi: 10.2174/1570162X21666230316110830.
HIV is one of the world's most devastating viral infections and has claimed tens of millions of lives worldwide since it was first identified in the 1980s. There is no cure for HIV infection. However, with tremendous progress in HIV diagnosis, prevention, and treatment, HIV has become a manageable chronic health disease. CCR5 is an important coreceptor used by HIV to infect target cells, and genetic deficiency of the chemokine receptor CCR5 confers a significant degree of protection against HIV infection. In addition, since CCR5 deficiency does not appear to cause any adverse health effects, targeting this coreceptor is a promising strategy for the treatment and prevention of HIV. Monoclonal antibodies are frequently used as therapeutics for many diseases and therefore are being used as a potential therapy for HIV-1 infection. This review reports on CCR5 antibody research in detail and describes the role and advantages of CCR5 antibodies in HIV prevention or treatment, introduces several main CCR5 antibodies, and discusses the future strategy of antibody-conjugated nanoparticles including the potential challenges. CCR5 antibodies may be a novel therapy for treating HIV infection effectively and could overcome the limitations of the currently available options.
HIV 是世界上最具破坏性的病毒感染之一，自 20 世纪 80 年代首次被发现以来，已在全球夺走了数千万人的生命。目前还没有治愈 HIV 感染的方法。然而，随着 HIV 诊断、预防和治疗方面的巨大进展，HIV 已成为一种可管理的慢性健康疾病。CCR5 是 HIV 感染靶细胞的重要辅助受体，趋化因子受体 CCR5 的遗传缺陷赋予对 HIV 感染的显著程度的保护。此外，由于 CCR5 缺乏似乎不会引起任何不良健康影响，因此靶向该辅助受体是治疗和预防 HIV 的一种有前途的策略。单克隆抗体常用于许多疾病的治疗，因此被用作 HIV-1 感染的潜在治疗方法。本综述详细报告了 CCR5 抗体的研究，并描述了 CCR5 抗体在 HIV 预防或治疗中的作用和优势，介绍了几种主要的 CCR5 抗体，并讨论了包括潜在挑战在内的抗体偶联纳米颗粒的未来策略。CCR5 抗体可能是一种有效治疗 HIV 感染的新疗法，可以克服现有治疗方案的局限性。
