Yazdanpanah Zeinab, Salehi-Abargouei Amin, Mollahosseini Mehdi, Sheikhha Mohammad Hasan, Mirzaei Masoud, Mozaffari-Khosravi Hassan
Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Br J Nutr. 2023 Nov 14;130(9):1510-1520. doi: 10.1017/S0007114523000570. Epub 2023 Mar 16.
Several studies have examined the association between rs1761667 polymorphism with cardiometabolic risk factors and metabolic syndrome (MetS). This study aimed to investigate the interactions between rs1761667 polymorphism and dietary patterns on the cardiometabolic risk factors and the risk of MetS in apparently healthy individuals aged 20-70 years. Food consumption data were acquired using a validated semi-quantitative FFQ. Dietary patterns were identified by factor analysis. rs1761667 was genotyped by PCR-restriction fragment length polymorphism. The gene-diet interaction was detected by the general linear model or logistic regression. Significant or marginally significant interactions were observed between healthy dietary pattern (HDP) and rs1761667 on weight ( = 0·006), BMI ( = 0·009), waist circumference ( = 0·005), hip circumference ( = 0·06), body muscle percentage ( = 0·02), body fat percentage ( = 0·09), TAG-glucose index ( = 0·057), atherogenic index of plasma ( = 0·07), the risk of MetS ( = 0·02), risk of abdominal obesity ( = 0·02) and elevated blood pressure ( = 0·07). Besides, a gene-diet interaction was detected between the traditional dietary pattern and rs1761667 variants on odds of hypertriglyceridaemia ( = 0·02). The adherence to HDP was associated with a lower weight, BMI and higher odds of HDL-cholesterol only in A-allele carriers. In conclusion, adherence to HDP (a diet with high fibre, fish and dairy products) can be more effective on some cardiometabolic risk factors and risk of MetS components in the A-allele carrier than the GG genotype of rs1761667 polymorphism. However, future studies are required to shed light on this issue.
多项研究探讨了rs1761667基因多态性与心血管代谢危险因素及代谢综合征（MetS）之间的关联。本研究旨在调查rs1761667基因多态性与饮食模式对20至70岁表面健康个体的心血管代谢危险因素及MetS风险的相互作用。通过经过验证的半定量食物频率问卷（FFQ）获取食物消费数据。通过因子分析确定饮食模式。采用聚合酶链反应-限制性片段长度多态性方法对rs1761667进行基因分型。通过一般线性模型或逻辑回归检测基因-饮食相互作用。在健康饮食模式（HDP）与rs1761667之间观察到在体重（P = 0·006）、体重指数（BMI，P = 0·009）、腰围（P = 0·005）、臀围（P = 0·06）、身体肌肉百分比（P = 0·02）、体脂百分比（P = 0·09）、甘油三酯-葡萄糖指数（P = 0·057）、血浆致动脉粥样硬化指数（P = 0·07）、MetS风险（P = 0·02）、腹部肥胖风险（P = 0·02）和血压升高（P = 0·07）方面存在显著或边缘显著的相互作用。此外，在传统饮食模式与rs1761667变异体之间检测到在高甘油三酯血症几率方面存在基因-饮食相互作用（P = 0·02）。仅在A等位基因携带者中，坚持HDP与较低的体重、BMI以及较高的高密度脂蛋白胆固醇几率相关。总之，对于rs1761667基因多态性的A等位基因携带者，坚持HDP（富含纤维、鱼类和乳制品的饮食）在某些心血管代谢危险因素及MetS组分风险方面可能比GG基因型更有效。然而，需要未来的研究来阐明这一问题。
