State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China.
Yi Chuan. 2022 Dec 20;44(12):1103-1116. doi: 10.16288/j.yczz.22-136.
Spermatogonial stem cells (SSCs) are germ cells (GCs) with long-term self-renewal and differentiation potential in testis, namely tissue stem cells located on the basement membrane, whose self-renewal and differentiation are regulated by the surrounding microenvironment. In recent years, the research of SSCs has made a series of important progress, which brings the hope for the clinical treatment of some male infertility patients. Among them, the microenvironment is particularly important in regulating SSCs. The microenvironment is responsible for integrating the effects of different types of cell components, extracellular matrix, extracellular regulatory molecules and hormones on SSCs, thus regulating the fate of SSCs. The research on SSCs microenvironment has gradually become one of the main contents of stem cell research. In this review, we mainly summarize the cell composition, regulatory factors and characteristics of mouse SSCs microenvironment, thereby providing background information for in-depth study on the structure and function of SSCs microenvironment, and opportunity to find more abundant cell phenotypes and microenvironmental factors through multiple research models in the future.
精原干细胞（SSCs）是睾丸中具有长期自我更新和分化潜能的生殖细胞（GCs），即位于基膜上的组织干细胞，其自我更新和分化受周围微环境的调节。近年来，SSCs 的研究取得了一系列重要进展，为一些男性不育症患者的临床治疗带来了希望。其中，微环境在调节 SSCs 方面尤为重要。微环境负责整合不同类型的细胞成分、细胞外基质、细胞外调节分子和激素对 SSCs 的影响，从而调节 SSCs 的命运。SSCs 微环境的研究逐渐成为干细胞研究的主要内容之一。在这篇综述中，我们主要总结了小鼠 SSCs 微环境的细胞组成、调节因子和特点，从而为深入研究 SSCs 微环境的结构和功能提供背景信息，并为未来通过多种研究模型发现更丰富的细胞表型和微环境因素提供机会。
