Center for Economics and Development Studies (CEDS), Department of Economics, Faculty of Economics and Business, Universitas Padjadjaran.
Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin Hospital, Bandung.
AIDS. 2023 Jul 1;37(8):1189-1201. doi: 10.1097/QAD.0000000000003547. Epub 2023 Mar 14.
To estimate and compare the cost of improved test and treat strategies in Indonesia under HIV Awal (Early) Testing and Treatment Indonesia (HATI) implementation trial in community-based and hospital-based clinics.
The cost and outcome [i.e. CD4 + cell count] and viral load (VL) at the beginning of interventions and their change overtime) analysis of Simplifying ART Initiation (SAI), Community-based Organization and community-based ART Service (CBO), Motivational Interviewing (MI), Oral Fluid-based Testing (OFT), and Short Message Service (SMS) reminder in community-based and hospital-based clinics in 2018-2019.
We estimated the total and unit costs per patient (under HATI implementation trial interventions) per year from societal perspective in various settings, including costs from patients' perspective for SAI and MI. We also analyzed the outcome variables (i.e. CD4 + cell count and VL at the beginning of each intervention, the change in CD4 + cell count and VL over time, and adherence rate).
The unit cost per patient per year of SAI and SMS were lower at the community-based clinics, and more patients visited community-based clinics. The cost per patient visit from patient perspective for SAI and MI was mostly lower than 10% of the patients' household monthly expenditure. Average CD4 + cell count was higher and average VL was lower at the start of interventions at the community-based clinics, while average CD4 + cell count and VL changes and adherence rate were similar between the two types of clinics.
Community-based clinics hold the potential for scaling up the interventions as it costs less from societal perspective and showed better outcome improvement during the HATI implementation trial.
在印度尼西亚艾滋病早期检测和治疗印度尼西亚(HATI)实施试验中,估计并比较社区和医院诊所中改进的检测和治疗策略的成本。
2018-2019 年,在社区和医院诊所中,对简化抗逆转录病毒治疗启动(SAI)、社区组织和社区艾滋病服务(CBO)、动机访谈(MI)、口腔液检测(OFT)和短信提醒(SMS)干预措施开始时的成本和结果(即 CD4+细胞计数)以及病毒载量(VL)及其随时间的变化进行分析。
我们从社会角度估算了各种环境下每位患者(在 HATI 实施试验干预下)每年的总费用和单位费用,包括 SAI 和 MI 从患者角度的费用。我们还分析了结果变量(即每次干预开始时的 CD4+细胞计数和 VL、CD4+细胞计数和 VL 的随时间变化以及依从率)。
SAI 和 SMS 的每位患者每年的单位社区诊所费用较低,且更多患者到社区诊所就诊。从患者角度来看,SAI 和 MI 的每位患者就诊费用大多低于患者家庭月支出的 10%。社区诊所的干预开始时平均 CD4+细胞计数较高,平均 VL 较低,而两种类型的诊所之间的平均 CD4+细胞计数和 VL 变化和依从率相似。
从社会角度来看,社区诊所的成本较低,并且在 HATI 实施试验中显示出更好的结果改善,因此具有扩大干预措施的潜力。