Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece.
Curr Opin Cardiol. 2023 Jul 1;38(4):352-357. doi: 10.1097/HCO.0000000000001047. Epub 2023 Mar 14.
The purpose of this review was to present updated evidence on the role of skeletal muscle mass on cardiometabolic health.
Increased lean, and especially skeletal, muscle mass has been associated with better cardiometabolic health in various epidemiological studies, even in younger age groups. In addition, the link between skeletal muscle mass and adult lipid profile is of interest. A preliminary analysis using the data from the ATTICA prospective cohort study (2002-2022) supports this association.
Skeletal muscle mass has many metabolic functions (i.e., glucose, insulin and protein metabolism, mitochondrial function, arterial stiffness, inflammation, oxidative stress, brain function, hormone status). Given its associations with the lipid profile and overall cardiometabolic risk, skeletal muscle mass stands among the emerging risk factors for cardiovascular diseases. In addition to only using body mass index or fat distribution, more studies should evaluate lean mass and its prognostic and predictive ability regarding chronic diseases.
本综述旨在呈现骨骼肌质量与心脏代谢健康关系的最新证据。
在各种流行病学研究中，尤其是在年轻人群中，增加瘦体重和骨骼肌质量与更好的心脏代谢健康相关。此外，骨骼肌质量与成人血脂谱之间的关联也引起了关注。使用 ATTICA 前瞻性队列研究（2002-2022 年）的数据进行的初步分析支持这种关联。
骨骼肌质量具有许多代谢功能（即葡萄糖、胰岛素和蛋白质代谢、线粒体功能、动脉僵硬、炎症、氧化应激、大脑功能、激素状态）。鉴于其与血脂谱和整体心脏代谢风险的关联，骨骼肌质量成为心血管疾病的新兴危险因素之一。除了仅使用体重指数或脂肪分布外，还应开展更多研究评估瘦体重及其对慢性病的预后和预测能力。
