低钠血症和正常血清钠水平降低与心力衰竭患者全因死亡风险增加相关。

Hyponatremia and lower normal serum sodium levels are associated with an increased risk of all-cause death in heart failure patients.

机构信息

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, China.

出版信息

Nurs Open. 2023 Jun;10(6):3799-3809. doi: 10.1002/nop2.1638. Epub 2023 Mar 16.

AIM

To explore the relationship between the serum sodium level on admission and all-cause mortality in HF patients.

DESIGN

A single-center retrospective cohort study.

METHODS

Patients hospitalized with HF at the Heart Failure Center, Fuwai Hospital, from November 2008 to November 2018 were enrolled.

RESULTS

A total of 3649 patients were included, and the mean sodium level was 137.19 ± 4.36 mmol/L, with a range from 115.6 to 160.9 mmol/L. During a median follow-up of 1101 days, mortality occurred in 1413 (38.7%) hospital survivors. After adjustment for age, sex, and other potential confounders, patients with sodium levels <135 mmol/L (hazard ratio [HR]: 1.67; 95% confidence interval [CI]: 1.29-2.16) and 135-137 mmol/L (HR: 1.34; 95% CI: 1.01-1.78) had an increased risk of all-cause mortality compared to those with sodium levels of 139-141 mmol/L.

目的

探讨入院时血清钠水平与心力衰竭（HF）患者全因死亡率之间的关系。

设计

单中心回顾性队列研究。

方法

纳入 2008 年 11 月至 2018 年 11 月在阜外医院心力衰竭中心住院的 HF 患者。

结果

共纳入 3649 例患者，平均血清钠水平为 137.19±4.36mmol/L，范围为 115.6 至 160.9mmol/L。中位随访 1101 天期间，1413 例（38.7%）住院幸存者死亡。在校正年龄、性别和其他潜在混杂因素后，血清钠水平<135mmol/L（风险比[HR]：1.67；95%置信区间[CI]：1.29-2.16）和 135-137mmol/L（HR：1.34；95% CI：1.01-1.78）的患者全因死亡率风险高于血清钠水平为 139-141mmol/L 的患者。